Tetrahydroamentoflavone

Tetrahydroamentoflavone
Product Name Tetrahydroamentoflavone
CAS No.: 48236-96-0
Catalog No.: CFN98755
Molecular Formula: C30H22O10
Molecular Weight: 542.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: COX | Xanthine oxidase
Source: The herbs of Selaginella uncinata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Tetrahydroamentoflavone is a potent XO inhibitor, may be considered as a drug candidate or chemopreventive agent; it has anti-inflammatory effects, it shows in vitro cyclooxygenase (COX) inhibition activity ( an IC(50) value of 29.5 microM (COX-1) and 40.5% inhibition at 100 microg/mL (COX-2)). (2S,2″S )-Tetrahydroamentoflavone exerts its antioxidant activity in vitro through metal-chelating, and radical-scavenging, which is via donating a hydrogen atom (H61) and an electron (e).
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Front Immunol.2018, 9:2655
  • South African J of Plant&Soil2018, 29-32
  • Front Microbiol.2019, 10:2806
  • J Nat Prod.2015, 78(6):1339-4
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • BMC Complement Altern Med.2014, 14:352
  • Oncology Letters2018, 4690-4696
  • Sci Rep.2015, 5:13194
  • Industrial Crops and Products2019, 140:111612
  • Sciadopitysin

    Catalog No: CFN98847
    CAS No: 521-34-6
    Price: $288/20mg
    7''-O-Methylsciadopitysin

    Catalog No: CFN96118
    CAS No: 3778-25-4
    Price: Inquiry(manager@chemfaces.com)
    Taiwanhomoflavone A

    Catalog No: CFN96541
    CAS No: 265120-00-1
    Price: Inquiry(manager@chemfaces.com)
    3,8'-Biapigenin

    Catalog No: CFN99025
    CAS No: 101140-06-1
    Price: $418/5mg
    GB 1a

    Catalog No: CFN96934
    CAS No: 220611-41-6
    Price: Inquiry(manager@chemfaces.com)
    GB 1b

    Catalog No: CFN89091
    CAS No: 19360-72-6
    Price: Inquiry(manager@chemfaces.com)
    GB 2a

    Catalog No: CFN89133
    CAS No: 18412-96-9
    Price: Inquiry(manager@chemfaces.com)
    Wikstrol A

    Catalog No: CFN92960
    CAS No: 159736-35-3
    Price: Inquiry(manager@chemfaces.com)
    Cupressuflavone

    Catalog No: CFN70356
    CAS No: 3952-18-9
    Price: Inquiry(manager@chemfaces.com)
    4',4'''-Di-O-methylcupressuflavone

    Catalog No: CFN97224
    CAS No: 74336-91-7
    Price: Inquiry(manager@chemfaces.com)
    J Ethnopharmacol. 2011 Feb 16;133(3):1117-20.
    Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase.[Pubmed: 20965242]
    Seed of Semecarpus anacardium L. is widely used in Indian traditional medicine; Ayurveda and Sidha, for treatment of inflammatory disorders and gout. The present study was aimed at isolation of a compound for its potential to inhibit xanthine oxidase (XO), over expression of which lead to inflammation and gout.
    METHODS AND RESULTS:
    Activity guided fractionation of S. anacardium seed was conducted using liquid-liquid partition and preparative HPLC. The fractions were evaluated for their XO inhibition and antioxidant activity. The ethyl acetate fraction with the highest XO activity yielded a biflavonoid compound Tetrahydroamentoflavone (THA). Lineweaver-Burk (LB) plot for the XO inhibition of THA and allopurinol was constructed from the kinetic data. IC₅₀ values of THA and allopurinol for XO inhibition were 92 and 100 nM respectively and their corresponding values for K(i) were 0.982 and 0.612 μM respectively.
    CONCLUSIONS:
    THA was a potent XO inhibitor which could be considered as a drug candidate or chemopreventive agent, after establishing its pharmacological and clinical evaluation. The study results appear to support the claim of the traditional medicine with respect to the efficacy of S. anacardium seed against inflammation and gout.
    Natural Product Communications, 2013 ,8 (6) :787-9.
    Antioxidant Activity and Mechanism of Tetrahydroamentoflavone in vitro[Reference: WebLink]
    (2S,2″S )-Tetrahydroamentoflavone (THA) is a typical biflavonoid.
    METHODS AND RESULTS:
    In this study, we systematically evaluated its antioxidant activity by various antioxidant assays in vitro. The IC50 values of THA were 4.8±0.3, 743.2±49.5, 35.5±1.9, 165.7±22.8, 4.4±0.2, and 77.1±2.2 μg/mL, respectively, for superoxide (61O2-) radical-scavenging, Fe2+-chelating, Cu2+-chelating, DPPH61 (1,1-diphenyl-2-picrylhydrazyl radical) scavenging, ABTS61+ (3-ethylbenzthiazoline-6-sulfonic acid radical) scavenging, and Cu2+-reducing power. The average ratio value of IC50,Trolox:IC50,THA was calculated as 2.54, suggesting that THA possesses 2.54 times the total antioxidant level than the standard antioxidant Trolox.
    CONCLUSIONS:
    THA exerts its antioxidant activity in vitro through metal-chelating, and radical-scavenging, which is via donating a hydrogen atom (H61) and an electron (e). Its antioxidant activity can be responsible for its pharmacological effect and make it an attractive natural antioxidant.
    J Ethnopharmacol. 2004 Dec;95(2-3):209-12.
    A cyclooxygenase (COX) inhibitory biflavonoid from the seeds of Semecarpus anacardium.[Pubmed: 15507338 ]
    Semecarpus anacardium Linn., Anacardiaceae, is being most commonly used in India for the treatment of rheumatoid arthritis and other inflammatory disorders.
    METHODS AND RESULTS:
    Bioactivity guided fractionation of ethyl acetate extract led to the isolation of major active principle, Tetrahydroamentoflavone (THA), a biflavonoid. The in vitro cyclooxygenase (COX-1) catalyzed prostaglandin biosynthesis assay of THA gave an IC(50) value of 29.5 microM (COX-1) and 40.5% inhibition at 100 microg/mL (COX-2). The in vivo carrageenan induced paw edema assay resulted in dose dependent anti-inflammatory effect of THA and the activity was comparable to that of ibuprofen, one of the well known NSAIDs.
    (-)-Catechin gallate(CG)

    Catalog No: CFN98504
    CAS No: 130405-40-2
    Price: $348/20mg
    Pinoresinol

    Catalog No: CFN98775
    CAS No: 487-36-5
    Price: $268/20mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $218/20mg
    Naringin 4'-glucoside

    Catalog No: CFN95014
    CAS No: 17257-21-5
    Price: $338/5mg
    Poricoic acid B

    Catalog No: CFN95050
    CAS No: 137551-39-4
    Price: $368/10mg
    Suspenoidside B

    Catalog No: CFN95071
    CAS No: 2161432-08-0
    Price: $413/5mg
    Cyclocurcumin

    Catalog No: CFN95103
    CAS No: 153127-42-5
    Price: $318/5mg
    New compound 2

    Catalog No: CFN95181
    CAS No: N/A
    Price: $318/5mg
    4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol

    Catalog No: CFN95200
    CAS No: 913643-31-9
    Price: $368/5mg
    N-Methylcorydalmine

    Catalog No: CFN95204
    CAS No: 81010-29-9
    Price: $398/5mg