Podocarpusflavone A

Podocarpusflavone A
Product Name Podocarpusflavone A
CAS No.: 22136-74-9
Catalog No.: CFN98202
Molecular Formula: C31H20O10
Molecular Weight: 552.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: DNA/RNA Synthesis | Antifection
Source: The barks of Podocarpus macrophyllus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Podocarpusflavone A is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever. Podocarpusflavone A also shows antimalarial activity in vitro against the chloroquine-sensitive F32 and chloroquine-resistant FcM29 strains of Plasmodium falciparum.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Phytomedicine.2019, 58:152893
  • Phytochem Anal.2021, 32(6):970-981.
  • LWT2024, v208:116677
  • Foods2023, 12(23), 4342.
  • Front Plant Sci.2022, 13: 905275.
  • Appl Biol Chem2019, 62:46
  • J Sci Food Agric.2022, 102(4):1628-1639
  • Evid Based Complement Alternat Med.2022, 2022:1307173.
  • Food Chem.2021, 337:128023.
  • Biomed Chromatogr.2019, 8:e4774
  • Podocarpusflavone A

    Catalog No: CFN98202
    CAS No: 22136-74-9
    Price: Inquiry(manager@chemfaces.com)
    Putraflavone

    Catalog No: CFN98246
    CAS No: 23624-21-7
    Price: Inquiry(manager@chemfaces.com)
    Heveaflavone

    Catalog No: CFN98236
    CAS No: 23132-13-0
    Price: Inquiry(manager@chemfaces.com)
    Isoginkgetin

    Catalog No: CFN90174
    CAS No: 548-19-6
    Price: $218/20mg
    Sciadopitysin

    Catalog No: CFN98847
    CAS No: 521-34-6
    Price: $288/20mg
    7''-O-Methylsciadopitysin

    Catalog No: CFN96118
    CAS No: 3778-25-4
    Price: Inquiry(manager@chemfaces.com)
    Taiwanhomoflavone A

    Catalog No: CFN96541
    CAS No: 265120-00-1
    Price: Inquiry(manager@chemfaces.com)
    3,8'-Biapigenin

    Catalog No: CFN99025
    CAS No: 101140-06-1
    Price: $318/5mg
    GB 1a

    Catalog No: CFN96934
    CAS No: 220611-41-6
    Price: Inquiry(manager@chemfaces.com)
    GB 1b

    Catalog No: CFN89091
    CAS No: 19360-72-6
    Price: Inquiry(manager@chemfaces.com)
    Planta Med. 2012 May;78(7):672-7.
    Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase.[Pubmed: 22411725]
    In order to find new molecules for antiviral drug design, we screened 102 ethyl acetate extracts from New-Caledonian flora for antiviral activity against the dengue 2 virus RNA-dependant RNA polymerase (DV-NS5 RdRp).
    METHODS AND RESULTS:
    The leaf extract of Dacrydium balansae, which strongly inhibited the DV-NS5, was submitted to bioguided fractionation. Four biflavonoids ( 1- 4), three sterols ( 5- 7), and two stilbene derivatives ( 8- 9) were identified and evaluated for their antiviral potential on the DV-NS5 RdRp. Biflavonoids appeared to be potent inhibitors of DV-NS5 RdRp with IC (50)s between 0.26 and 3.12 µM. Inhibitory activity evaluations against the RNA polymerase from other Flaviviridae viruses allowed us to conclude that these compounds are specific inhibitors of the DV RNA polymerase. The strongest inhibitions were observed with hinokiflavone ( 4), but Podocarpusflavone A ( 2) is the strongest noncytotoxic inhibitor of the DV-NS5 and it also displayed polymerase inhibitory activity in a DV replicon.
    CONCLUSIONS:
    A preliminary structure-activity relationship study (SARs) revealed the necessity of the biflavonoid skeleton, the influence of number and position of methoxylations, and the importance of a free rotation of the linkage between the two apigenin monomers of the biflavonoids. To the best of our knowledge, Podocarpusflavone A ( 2) is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever.
    Ann Trop Med Parasitol. 2007 Jan;101(1):23-30.
    Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola (Guttiferae).[Pubmed: 17244407 ]

    METHODS AND RESULTS:
    Phytochemical investigation of the leaves of Allanblackia monticola led to the isolation and characterisation of five prenylated xanthones [1,6-dihydroxy-3,7-dimethoxy-2-(3-methylbut-2-enyl)xanthone 1, alpha-mangostin 2, tovophyllin A 3, allanxanthone C 4 and 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthone 5], two biflavonoid derivatives (amentoflavone 6 and Podocarpusflavone A 7) and one pentacyclic triterpene (friedelan-3-one 8). The structures of these compounds were established on the basis of homo- and hetero-nuclear, one- and two-dimensional, nuclear magnetic resonance. Compounds 2-8 and a crude methanolic extract of A. monticola leaves were each tested for antimalarial activity in vitro, using the chloroquine-sensitive F32 and chloroquine-resistant FcM29 strains of Plasmodium falciparum; the median inhibitory concentrations (IC(50)) recorded varied from 0.7 to 83.5 mug/ml. The cytotoxicities of the compounds and crude extract, against cultures of human melanoma cells (A375), were then investigated, and cytotoxicity/antimalarial IC(50) ratios of 0.6-16.75 were recorded.
    CONCLUSIONS:
    In tests involving aortic rings from guinea pigs, a crude extract of the leaves of A. monticola was found to induce concentration-dependent vasorelaxation, causing up to 82% and 42% inhibition of noradrenaline- and KCl-induced contractions, respectively. The corresponding values for compounds 2 and 6 when tested against noradrenaline-induced contractions were approximately 18% and 35%, respectively.
    Carasinol D

    Catalog No: CFN95044
    CAS No: 1072797-66-0
    Price: $333/5mg
    Maculosidin

    Catalog No: CFN95126
    CAS No: 522-19-0
    Price: $413/5mg
    Silybin A

    Catalog No: CFN95149
    CAS No: 22888-70-6
    Price: $318/20mg
    Specioside B

    Catalog No: CFN95165
    CAS No: 126589-95-5
    Price: $368/5mg
    (-)-Cadin-4,10(15)-dien-11-oic acid

    Catalog No: CFN95246
    CAS No: 1124353-23-6
    Price: $318/5mg
    Eriodictyol 7-O-glucuronide

    Catalog No: CFN95290
    CAS No: 125535-06-0
    Price: $318/10mg
    Sophoraflavone A

    Catalog No: CFN95510
    CAS No: 105594-08-9
    Price: $318/10mg
    Caffeoylcalleryanin

    Catalog No: CFN95532
    CAS No: 20300-49-6
    Price: $318/10mg
    12-Acetoxy ganoderic acid D

    Catalog No: CFN95535
    CAS No: N/A
    Price: $318/5mg
    Ephedrannin D1

    Catalog No: CFN95547
    CAS No: 1592431-55-4
    Price: $318/5mg