Podocarpusflavone A

Podocarpusflavone A
Product Name Podocarpusflavone A
CAS No.: 22136-74-9
Catalog No.: CFN98202
Molecular Formula: C31H20O10
Molecular Weight: 552.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: DNA/RNA Synthesis | Antifection
Source: The barks of Podocarpus macrophyllus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Podocarpusflavone A is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever. Podocarpusflavone A also shows antimalarial activity in vitro against the chloroquine-sensitive F32 and chloroquine-resistant FcM29 strains of Plasmodium falciparum.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Front Pharmacol.2019, 10:1355
  • Front Cell Infect Microbiol.2018, 8:292
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • Sci Adv.2018, 4(10)
  • Srinagarind Medical Journal2019, 34(1)
  • Plant Growth Regulation2020, 90(2):383-392
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Int J Mol Sci.2015, 16(8):18396-411
  • J Hematol Oncol.2018, 11(1):112
  • Primary and Industrial.2018, 52(11)
  • Wikstrol A

    Catalog No: CFN92960
    CAS No: 159736-35-3
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN70356
    CAS No: 3952-18-9
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN97224
    CAS No: 74336-91-7
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN95007
    CAS No: 135309-02-3
    Price: $418/5mg

    Catalog No: CFN96555
    CAS No: 948884-38-6
    Price: Inquiry(manager@chemfaces.com)
    2,3-Dihydroamentoflavone 7,4'-dimethyl ether

    Catalog No: CFN96163
    CAS No: 873999-88-3
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN96119
    CAS No: 110382-42-8
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN96134
    CAS No: 34421-19-7
    Price: Inquiry(manager@chemfaces.com)
    2,3-Dihydropodocarpusflavone A

    Catalog No: CFN96378
    CAS No: 852875-96-8
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN98755
    CAS No: 48236-96-0
    Price: Inquiry(manager@chemfaces.com)
    Planta Med. 2012 May;78(7):672-7.
    Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase.[Pubmed: 22411725]
    In order to find new molecules for antiviral drug design, we screened 102 ethyl acetate extracts from New-Caledonian flora for antiviral activity against the dengue 2 virus RNA-dependant RNA polymerase (DV-NS5 RdRp).
    The leaf extract of Dacrydium balansae, which strongly inhibited the DV-NS5, was submitted to bioguided fractionation. Four biflavonoids ( 1- 4), three sterols ( 5- 7), and two stilbene derivatives ( 8- 9) were identified and evaluated for their antiviral potential on the DV-NS5 RdRp. Biflavonoids appeared to be potent inhibitors of DV-NS5 RdRp with IC (50)s between 0.26 and 3.12 µM. Inhibitory activity evaluations against the RNA polymerase from other Flaviviridae viruses allowed us to conclude that these compounds are specific inhibitors of the DV RNA polymerase. The strongest inhibitions were observed with hinokiflavone ( 4), but Podocarpusflavone A ( 2) is the strongest noncytotoxic inhibitor of the DV-NS5 and it also displayed polymerase inhibitory activity in a DV replicon.
    A preliminary structure-activity relationship study (SARs) revealed the necessity of the biflavonoid skeleton, the influence of number and position of methoxylations, and the importance of a free rotation of the linkage between the two apigenin monomers of the biflavonoids. To the best of our knowledge, Podocarpusflavone A ( 2) is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever.
    Ann Trop Med Parasitol. 2007 Jan;101(1):23-30.
    Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola (Guttiferae).[Pubmed: 17244407 ]

    Phytochemical investigation of the leaves of Allanblackia monticola led to the isolation and characterisation of five prenylated xanthones [1,6-dihydroxy-3,7-dimethoxy-2-(3-methylbut-2-enyl)xanthone 1, alpha-mangostin 2, tovophyllin A 3, allanxanthone C 4 and 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthone 5], two biflavonoid derivatives (amentoflavone 6 and Podocarpusflavone A 7) and one pentacyclic triterpene (friedelan-3-one 8). The structures of these compounds were established on the basis of homo- and hetero-nuclear, one- and two-dimensional, nuclear magnetic resonance. Compounds 2-8 and a crude methanolic extract of A. monticola leaves were each tested for antimalarial activity in vitro, using the chloroquine-sensitive F32 and chloroquine-resistant FcM29 strains of Plasmodium falciparum; the median inhibitory concentrations (IC(50)) recorded varied from 0.7 to 83.5 mug/ml. The cytotoxicities of the compounds and crude extract, against cultures of human melanoma cells (A375), were then investigated, and cytotoxicity/antimalarial IC(50) ratios of 0.6-16.75 were recorded.
    In tests involving aortic rings from guinea pigs, a crude extract of the leaves of A. monticola was found to induce concentration-dependent vasorelaxation, causing up to 82% and 42% inhibition of noradrenaline- and KCl-induced contractions, respectively. The corresponding values for compounds 2 and 6 when tested against noradrenaline-induced contractions were approximately 18% and 35%, respectively.

    Catalog No: CFN99155
    CAS No: 5041-81-6
    Price: $138/20mg

    Catalog No: CFN98730
    CAS No: 479-43-6
    Price: $388/5mg
    Dehydropachymic acid

    Catalog No: CFN92742
    CAS No: 77012-31-8
    Price: $338/10 mg

    Catalog No: CFN96878
    CAS No: 65428-13-9
    Price: $413/5mg

    Catalog No: CFN95023
    CAS No: 74690-74-7
    Price: $413/5mg
    Lappaol A

    Catalog No: CFN95067
    CAS No: 62333-08-8
    Price: $333/10mg
    Magnaldehyde B

    Catalog No: CFN95075
    CAS No: 92829-72-6
    Price: $413/5mg
    2''-O-acetylsaikosaponin A

    Catalog No: CFN95085
    CAS No: 102934-42-9
    Price: $318/5mg
    Cistantubuloside C1

    Catalog No: CFN95121
    CAS No: 620632-36-2
    Price: $298/10mg

    Catalog No: CFN95198
    CAS No: 75412-95-2
    Price: $318/10mg