7,4'-Di-O-methylapigenin

7,4'-Di-O-methylapigenin
Product Name 7,4'-Di-O-methylapigenin
CAS No.: 5128-44-9
Catalog No.: CFN98819
Molecular Formula: C17H14O5
Molecular Weight: 298.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The herbs of Aquilaria sinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Apigenin 7, 4'-dimethyl ether (7,4'-Di-O-methylapigenin) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Research Square2020, doi: 10.21203.
  • Exp Mol Med.2020, 52(4):629-642.
  • J Cell Physiol.2020, 10.1002
  • SBRAS2016, 12
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Chem. of Vegetable Raw Materials2020, 97-105
  • Separations2021, 8(1), 1.
  • Phytother Res.2019, 33(7):1784-1793
  • J Agric Food Chem.2016, 64(35):6783-90
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • 4',5,6,7-Tetramethoxyflavone

    Catalog No: CFN91034
    CAS No: 1168-42-9
    Price: $258/5mg
    6-Demethoxytangeretin

    Catalog No: CFN93255
    CAS No: 6601-66-7
    Price: $188/10mg
    Lysionotin

    Catalog No: CFN99787
    CAS No: 152743-19-6
    Price: $40/20mg
    Gardenin B

    Catalog No: CFN93144
    CAS No: 2798-20-1
    Price: $198/10mg
    Tangeretin

    Catalog No: CFN90240
    CAS No: 481-53-8
    Price: $30/20mg
    4',5-Dihydroxyflavone

    Catalog No: CFN97137
    CAS No: 6665-67-4
    Price: $70/20mg
    Apigenin

    Catalog No: CFN98843
    CAS No: 520-36-5
    Price: $40/20mg
    Genkwanin

    Catalog No: CFN98670
    CAS No: 437-64-9
    Price: $80/20mg
    Thevetiaflavone

    Catalog No: CFN96124
    CAS No: 29376-68-9
    Price: Inquiry(manager@chemfaces.com)
    Scutellarein

    Catalog No: CFN98557
    CAS No: 529-53-3
    Price: $80/20mg
    J. Food Sci.Technol., 2015, 52(6):3561-70.
    Effect on oxidative stress, glucose uptake level and lipid droplet content by Apigenin 7, 4'-dimethyl ether isolated from Piper longum L.[Pubmed: 26028738 ]

    METHODS AND RESULTS:
    Presence of apigenin 7, 4'-dimethyl ether(7,4'-Di-O-methylapigenin,ADE) and piperine (Pip) in EAP was determined by HPTLC analysis and was isolated. ADE inhibited α-glucosidase and α-amylase enzymes and enhanced 2-NBDG uptake in L6 cells. Hypolipidemic effect of ADE on mouse pre-adipocyte (3T3L1) cell lines also showed a dose dependent reduction on lipid droplet content and effective concentration range was determined as 1-2.5 μg/mL.
    CONCLUSIONS:
    The results suggested that Piper longum fruits can provide a natural source of antioxidants with antidiabetic and anti obesity potential.
    J Nat Prod. 1999 Feb;62(2):241-3.
    Five new flavone 5-O-glycosides from Lethedon tannaensis: lethedosides and lethediosides.[Pubmed: 10075750]

    METHODS AND RESULTS:
    Five new 7-methoxy-flavone 5-O-glycosides were isolated from a cytotoxic MeOH extract of Lethedon tannaensis, and the structures were elucidated by 2D NMR spectral analysis and by chemical methods. Lethedosides A (1), B (2), and C (3) were 5-O-glucosides of 7,3', 4'-tri-O-methylluteolin, 7,3',4',5'-tetra-O-methyltricetin, and 7,3', 4'-tri-O-methytricetin, respectively; lethediosides A (4) and B (5) and a known compound 6 were 5-O-xylosylglucosides of 7,3', 4'-tri-O-methylluteolin, 7,3',4',5'-tetra-O-methyltricetin, and 7,4'-Di-O-methylapigenin, respectively.
    CONCLUSIONS:
    These flavonoids were either inactive or weakly active against KB tumor cells, in contrast to previously isolated flavones from the same plant.
    Buddlenoid A

    Catalog No: CFN95025
    CAS No: 142750-32-1
    Price: $368/5mg
    Gymnoside III

    Catalog No: CFN95033
    CAS No: 899430-03-6
    Price: $318/10mg
    Angelol M

    Catalog No: CFN95060
    CAS No: 1092952-64-1
    Price: $288/5mg
    3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol

    Catalog No: CFN95123
    CAS No: 1221686-60-7
    Price: $398/5mg
    Pueroside C

    Catalog No: CFN95156
    CAS No: 112343-16-5
    Price: $368/5mg
    Bergaptol-beta-glucopyranoside

    Catalog No: CFN95186
    CAS No: 131623-13-7
    Price: $318/10mg
    Isomargaritene

    Catalog No: CFN95304
    CAS No: 64271-11-0
    Price: $318/10mg
    Deoxy euphorbia factor L1

    Catalog No: CFN95340
    CAS No: 247099-01-0
    Price: $318/10mg
    New compound 8

    Catalog No: CFN95341
    CAS No: N/A
    Price: $318/5mg
    Dipsacussaponin C

    Catalog No: CFN95353
    CAS No: 152406-43-4
    Price: $318/5mg