7,4'-Di-O-methylapigenin

7,4'-Di-O-methylapigenin
Product Name 7,4'-Di-O-methylapigenin
CAS No.: 5128-44-9
Catalog No.: CFN98819
Molecular Formula: C17H14O5
Molecular Weight: 298.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The herbs of Aquilaria sinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Apigenin 7, 4'-dimethyl ether (7,4'-Di-O-methylapigenin) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • J Ethnopharmacol.2017, 198:205-213
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Earth Environ. Sci. 2021, 905:012080.
  • Oncotarget.2017, 8(64):108006-108019
  • Nutr Cancer.2022, 1-13.
  • Heliyon.2023, 9:e21652.
  • Applied Biological Chemistry2020, 63:37.
  • Sci Rep. 2018, 462(8)
  • BMC Plant Biol.2018, 18(1):122
  • Scutellarein

    Catalog No: CFN98557
    CAS No: 529-53-3
    Price: $60/20mg
    Hispidulin

    Catalog No: CFN99491
    CAS No: 1447-88-7
    Price: $218/20mg
    Cirsimaritin

    Catalog No: CFN97126
    CAS No: 6601-62-3
    Price: $318/10mg
    Isoscutellarein

    Catalog No: CFN91491
    CAS No: 41440-05-5
    Price: Inquiry(manager@chemfaces.com)
    4'-Hydroxywogonin

    Catalog No: CFN98960
    CAS No: 57096-02-3
    Price: $268/10mg
    Isothymusin

    Catalog No: CFN97562
    CAS No: 98755-25-0
    Price: Inquiry(manager@chemfaces.com)
    Acacetin

    Catalog No: CFN98744
    CAS No: 480-44-4
    Price: $30/20mg
    7,4'-Di-O-methylapigenin

    Catalog No: CFN98819
    CAS No: 5128-44-9
    Price: Inquiry(manager@chemfaces.com)
    Trimethylapigenin

    Catalog No: CFN91890
    CAS No: 5631-70-9
    Price: $80/20mg
    Ladanein

    Catalog No: CFN96380
    CAS No: 10176-71-3
    Price: $318/5mg
    J. Food Sci.Technol., 2015, 52(6):3561-70.
    Effect on oxidative stress, glucose uptake level and lipid droplet content by Apigenin 7, 4'-dimethyl ether isolated from Piper longum L.[Pubmed: 26028738 ]

    METHODS AND RESULTS:
    Presence of apigenin 7, 4'-dimethyl ether(7,4'-Di-O-methylapigenin,ADE) and piperine (Pip) in EAP was determined by HPTLC analysis and was isolated. ADE inhibited α-glucosidase and α-amylase enzymes and enhanced 2-NBDG uptake in L6 cells. Hypolipidemic effect of ADE on mouse pre-adipocyte (3T3L1) cell lines also showed a dose dependent reduction on lipid droplet content and effective concentration range was determined as 1-2.5 μg/mL.
    CONCLUSIONS:
    The results suggested that Piper longum fruits can provide a natural source of antioxidants with antidiabetic and anti obesity potential.
    J Nat Prod. 1999 Feb;62(2):241-3.
    Five new flavone 5-O-glycosides from Lethedon tannaensis: lethedosides and lethediosides.[Pubmed: 10075750]

    METHODS AND RESULTS:
    Five new 7-methoxy-flavone 5-O-glycosides were isolated from a cytotoxic MeOH extract of Lethedon tannaensis, and the structures were elucidated by 2D NMR spectral analysis and by chemical methods. Lethedosides A (1), B (2), and C (3) were 5-O-glucosides of 7,3', 4'-tri-O-methylluteolin, 7,3',4',5'-tetra-O-methyltricetin, and 7,3', 4'-tri-O-methytricetin, respectively; lethediosides A (4) and B (5) and a known compound 6 were 5-O-xylosylglucosides of 7,3', 4'-tri-O-methylluteolin, 7,3',4',5'-tetra-O-methyltricetin, and 7,4'-Di-O-methylapigenin, respectively.
    CONCLUSIONS:
    These flavonoids were either inactive or weakly active against KB tumor cells, in contrast to previously isolated flavones from the same plant.
    Scutellarein-7-O-glucoside

    Catalog No: CFN95082
    CAS No: 26046-94-6
    Price: $318/5mg
    Isololiolide

    Catalog No: CFN95106
    CAS No: 38274-00-9
    Price: $318/5mg
    1-Isomangostin

    Catalog No: CFN95114
    CAS No: 19275-44-6
    Price: $318/5mg
    Nortrachelogenin-5'-C-beta-glucoside

    Catalog No: CFN95251
    CAS No: 858127-39-6
    Price: $318/10mg
    Bidenoside C

    Catalog No: CFN95266
    CAS No: 700877-55-0
    Price: $318/5mg
    4,7-Didehydroneophysalin B

    Catalog No: CFN95317
    CAS No: 134461-76-0
    Price: $338/5mg
    Caffeic acid 4-O-glucuronide

    Catalog No: CFN95382
    CAS No: 1093679-71-0
    Price: Inquiry(manager@chemfaces.com)
    7-Oxodehydroabietic acid

    Catalog No: CFN95411
    CAS No: 18684-55-4
    Price: $318/5mg
    Otobaphenol

    Catalog No: CFN95476
    CAS No: 10240-16-1
    Price: $318/10mg
    Odontoside

    Catalog No: CFN95530
    CAS No: 20300-50-9
    Price: $318/5mg