Product Name Cirsimaritin
CAS No.: 6601-62-3
Catalog No.: CFN97126
Molecular Formula: C17H14O6
Molecular Weight: 314.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: Tyrosinase | cAMP | PKA | Akt | NADPH-oxidase | Calcium Channel | TNF-α | Antifection
Source: The herbs of Microtea debilis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/10mg
Cirsimaritin has antibacterial, anti- inflammation, anti-tumor, antioxidant, renal protection and so on, it has potential use in patients with congestive heart failure, it can mitigate cardiac remodeling and left ventricular dysfunction through augmenting myocardial autophagy and decreasing matrix metalloproteinase-2&9 activities. Cirsimaritin inhibits the growth of tumor cells and induced mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner;support the putative application of cirsimaritin in ultraviolet photoprotection and hair coloration treatments.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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  • Cirsimaritin

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    Int J Mol Sci. 2015 Apr 20;16(4):8772-88.
    Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.[Pubmed: 25903150]
    The melanin-inducing properties of Cirsimaritin were investigated in murine B16F10 cells. Cirsimaritin is an active flavone with methoxy groups, which is isolated from the branches of Lithocarpus dealbatus.
    Tyrosinase activity and melanin content in murine B16F10 melanoma cells were increased by Cirsimaritin in a dose-dependent manner. Western blot analysis revealed that tyrosinase, tyrosinase-related protein (TRP) 1, TRP2 protein levels were enhanced after treatment with Cirsimaritin for 48 h. Cirsimaritin also upregulated the expression of microphthalmia-associated transcription factor (MITF) after 24 h of treatment. Furthermore, Cirsimaritin induced phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) in a dose-dependent manner after treatment for 15 min. The Cirsimaritin-mediated increase of tyrosinase activity was significantly attenuated by H89, a cAMP-dependent protein kinase A inhibitor. These findings indicate that Cirsimaritin stimulates melanogenesis in B16F10 cells by activation of CREB as well as upregulation of MITF and tyrosinase expression, which was activated by cAMP signaling. Finally, the melanogenic effect of Cirsimaritin was confirmed in human epidermal melanocytes.
    These results support the putative application of Cirsimaritin in ultraviolet photoprotection and hair coloration treatments.
    Cancer Lett. 2010 Sep 28;295(2):252-9.
    Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimaritin-induced apoptosis in human gallbladder carcinoma GBC-SD cells.[Pubmed: 20359814]
    In this study, the anticancer effect of Cirsimaritin, a natural flavonoid, against human gallbladder carcinoma cell line GBC-SD and the underlying mechanisms were investigated.
    Cirsimaritin inhibited the growth of tumor cells and induced mitochondrial apoptosis in GBC-SD cells. In addition, Cirsimaritin triggered endoplasmic reticulum (ER) stress and down-regulated the phosphorylation of Akt, while knock-down of CHOP dramatically abrogated the inactivation of Akt and reversed the pro-apoptotic effect of Cirsimaritin. Furthermore, Cirsimaritin provoked the generation of reactive oxygen species in GBC-SD cells, while the antioxidant N-acetyl cysteine almost completely blocked the activation of ER stress and apoptosis, suggesting Cirsimaritin-induced reactive oxygen species is an early event that triggers ER stress mitochondrial apoptotic pathways in GBC-SD cells.
    Int .J. Clin. Exp. Pathol .,2016;9(2):509-20.
    Cirsimaritin ameliorates cardiac remodeling and dysfunction through promoting myocardial autophagy in rats with heart failure.[Reference: WebLink]
    Cirsimaritin, a natural flavone, has been reported to exert various activities including antibacterial, anti-inflammation, anti-tumor, antioxidant, renal protection and so on. However, despite these pharmacological studies, whether Cirsimaritin alleviates heart failure is still unknown.
    Administration of isoproterenol led to a serious heart failure, as evidenced by the up-regulation of heart rate, weight index and end diastolic pressure of left ventricular, while by the down-regulation of left ventricular systolic pressure, maximal rate of pressure rise or decline of left ventricular. Pretreatment of Cirsimaritin significantly ameliorated these cardiac parameters in a dose-dependent manner. In addition, Cirsimaritin remarkably inhibited serum levels of Ang II, NE, TNF-α and BNP in rats with heart failure and attenuated the cardiac histological changes. Moreover, matrix metalloproteinase-2&9 activities were also suppressed by Cirsimaritin. Furthermore, myocardial autophagy was significantly promoted by Cirsimaritin in vivo and in vitro through inhibiting AKT1-RPS6KB1 signaling.
    These findings reveal that Cirsimaritin mitigates cardiac remodeling and left ventricular dysfunction through augmenting myocardial autophagy and decreasing matrix metalloproteinase-2&9 activities, suggesting its potential use in patients with congestive heart failure.
    Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):307-14.
    Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst by cirsimaritin involves inhibition of phospholipase D signaling in rat neutrophils.[Pubmed: 12237743]
    In this study, the cellular localization of the inhibitory effect of a natural flavonoid Cirsimaritin against formyl-methionyl-leucyl-phenylalanine (fMLP)-induced respiratory burst in rat neutrophils was investigated.
    Cirsimaritin concentration-dependently inhibited the superoxide anion (O(*-)(2))generation and O(2) consumption (IC(50) 11.5+/-2.2 micro M and 17.0+/-3.9 micro M, respectively) of neutrophils. Cirsimaritin did not reduce, but slightly enhanced the O(*-)(2) generation in phorbol 12-myristate 13-acetate (PMA)-activated or arachidonic acid-stimulated NADPH oxidase preparation as well as during the autoxidation of dihydroxyfumaric acid. Cirsimaritin did not elevate cellular cAMP levels, and only partially inhibited the fMLP-induced [Ca(2+)](i) changes in the presence or absence of extracellular Ca(2+). The phosphorylation of protein tyrosine, extracellular signal-regulated protein kinase and Akt caused by fMLP were attenuated by Cirsimaritin in a concentration-dependent manner. In contrast, Cirsimaritin had no effect on the phosphorylation of p38 mitogen-activated protein kinase. Cirsimaritin produced a concentration-dependent reduction in the formation of phosphatidic acid and phosphatidylethanol, in the presence of ethanol, from fMLP-stimulated neutrophils (IC(50) 15.1+/-6.5 micro M and 15.6+/-3.4 micro M, respectively), but did not affect the phosphatidylethanol formation in response to PMA. Under the similar concentration range, Cirsimaritin attenuated the membrane translocation of ARF and Rho A. However, the GTPgammaS-stimulated membrane-associated ARF and Rho in cell lysate were unaffected by Cirsimaritin.
    Collectively, these results indicate that the inhibition of fMLP-induced respiratory burst by Cirsimaritin in rat neutrophils is likely mainly through the blockade of phospholipase D signaling pathway.
    Fitoterapia. 2011 Mar;82(2):168-72.
    Flavonoid glycosides from Microtea debilis and their cytotoxic and anti-inflammatory effects.[Pubmed: 20804824]

    Two new 5-O-glucosylflavones, 5-O-β-D-glucopyranosyl Cirsimaritin (1) and 5, 4'-O-β-D-diglucopyranosyl Cirsimaritin (2), four known flavonoids, cirsimarin (3), Cirsimaritin (4), salvigenin (5), 4', 5-dihydroxy-7-methoxyflavone (6), and a norisoprenoid, vomifoliol (7), have been isolated from the aerial parts of Microtea debilis. All isolates were tested for cytotoxicity in human cancer cell lines (Hep G2, COLO 205, and HL-60) and anti-inflammatory activities in LPS-treated RAW264.7 macrophages. Compound 6 was found to be a potent inhibitor to nitrite production in macrophages.
    Compounds 2, 4, 6, and 7 showed moderate anti-proliferative activity against COLO-205 cells with IC(50) values of 7.1, 13.1, 6.1, and 6.8 μM, respectively.

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