Gypenoside XLVI | CAS:94705-70-1 | Manufacturer ChemFaces

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Postharvest Biol Tec2019, 149:18-26

Primary and Industrial.2018, 52(11)

Molecules.2023, 28(8):3503.

Korean J of Medicinal Crop Science2018, 220-226

Molecules.2024, 29(5):1048.

Curr Issues Mol Biol.2022, 44(10):5106-5116.

Life Sci.2022, 298:120488.

Turkish Journal of Pharmaceutical Sciences2022, DOI: 10.4274

BMC Plant Biol.2021, 21(1):60.

Chemistry of Plant Materials.2019, 129-136

Faseb J., 2014, 28(1).

Cytotoxic activity of gypenosides and gynogenin from Gynostemma pentaphyllum against A549 cells [Reference: WebLink]

Gynostemma pentaphyllum (Thunb.) Makino is one of the well-known traditional Chinese herbal medicines, which has been demonstrated to be effective against chronic diseases, such as lung cancer. In the present study, seven dammarane-type compounds were isolated from the raw, heat processed and alkaline hydrolyzed G. Pentaphyllum and compared for their cytotoxic activities against non-small cell lung carcinoma A549 cells using MTT cytotoxicity assay.
METHODS AND RESULTS:
By means of chemical and spectroscopic methods, their structures were established as gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α, 3β, 12β, 20-tetrol. Gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α,3β,12β,20-tetrol all showed strong cytotoxic activity against A549 cells, with the IC50 values of 105.89±2.48, 52.63±8.31, 34.94±4.23, 50.96±9.55, 26.98±0.51, 4.56±0.58, 12.54±0.53 μg/ml respectively, whereas the IC50 value of 20S-Rg3 (positive control) was 55.36±3.20 μg/ml. Comparing their structures with cytotoxic activity, these compounds might possess some kind of structure-activity relationship.
CONCLUSIONS:
Based on the structure and cytotoxic activity relationships of these seven constituents, the OH group in C-2, the double bond in C20(21) and C20(22) positions, the connected sugar number and the configuration in C-20 were important for cytotoxic activity against A549 cells.

Product Name	Gypenoside XLVI
CAS No.:	94705-70-1
Catalog No.:	CFN93372
Molecular Formula:	C₄₈H₈₂O₁₉
Molecular Weight:	963.2 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Panax notoginseng (Burk.) F.H.Chen
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$218/10mg