3,3',4',5,6,7,8-heptamethoxyflavone

3,3',4',5,6,7,8-heptamethoxyflavone
Product Name 3,3',4',5,6,7,8-heptamethoxyflavone
CAS No.: 1178-24-1
Catalog No.: CFN95021
Molecular Formula: C22H24O9
Molecular Weight: 432.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: TNF-α | IL Receptor | gp120/CD4 | NO | MMP(e.g.TIMP) | MAPK | ERK | JNK | TGF-β/Smad
Source: The peels of Citrus nobilis Lour.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $268/10mg
3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I procollagen synthesis in HDFn cells, and against nitric oxide (NO) carcinogenesis.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Korean J. of Food Sci. and TechApril 2016
  • J Drug Target.2016 Feb 24:1-28.
  • J Exp Bot. 2016 May 18.
  • Yakugaku Zasshi.2018 Jan 30;
  • Molecules. 2017 Feb 8;
  • Biofactors.2017 Oct 24.
  • Jou. of Agromedicine and Med. Sci.2018;
  • Journal of Pharmaceutical Analysis2016 May 5;
  • BangaloreOct/Dec 2017;
  • Tea Res. Ins. Of ChinaJuly 13, 2017;
  • Desmethoxycentaureidin

    Catalog No: CFN98234
    CAS No: 22934-99-2
    Price: Inquiry(manager@chemfaces.com)
    Eupatorin

    Catalog No: CFN97418
    CAS No: 855-96-9
    Price: $356/10mg
    Chrysoeriol

    Catalog No: CFN98785
    CAS No: 491-71-4
    Price: Inquiry(manager@chemfaces.com)
    Velutin

    Catalog No: CFN98290
    CAS No: 25739-41-7
    Price: $268/20mg
    Jaceosidin

    Catalog No: CFN90386
    CAS No: 18085-97-7
    Price: $198/20mg
    Cirsilineol

    Catalog No: CFN90418
    CAS No: 41365-32-6
    Price: Inquiry(manager@chemfaces.com)
    Isothymonin

    Catalog No: CFN92436
    CAS No: 99615-01-7
    Price: Inquiry(manager@chemfaces.com)
    5-Hydroxy-3',4',7-trimethoxyflavone

    Catalog No: CFN98361
    CAS No: 29080-58-8
    Price: $318/20mg
    Eupatilin

    Catalog No: CFN90190
    CAS No: 22368-21-4
    Price: $68/20mg
    Sinensetin

    Catalog No: CFN99599
    CAS No: 2306-27-6
    Price: $148/20mg
    Int J Mol Sci. 2018 Feb 22;19(2). pii: E620.
    3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells.[Pubmed: 29470423]
    Citrus fruits contain various types of flavonoids with powerful anti-aging and photoprotective effects on the skin, and have thus been attracting attention as potential, efficacious skincare agents.
    METHODS AND RESULTS:
    Here, we aimed to investigate the chemical composition of Citrus unshiu and its protective effects on photoaging. We isolated and identified a bioactive compound, 3,5,6,7,8,3',4'-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HMF), from C. unshiu peels using ethanol extraction and hexane fractionation. HMF inhibited collagenase activity and increased type I procollagen content in UV-induced human dermal fibroblast neonatal (HDFn) cells. HMF also suppressed the expression of matrix metalloproteinases 1 (MMP-1) and induced the expression of type I procollagen protein in UV-induced HDFn cells. Additionally, HMF inhibited ultraviolet B (UVB)-induced phosphorylation of the mitogen-activated protein kinases (MAPK) cascade signaling components-ERK, JNK, and c-Jun-which are involved in the induction of MMP-1 expression. Furthermore, HMF affected the TGF-β/Smad signaling pathway, which is involved in the regulation of type I procollagen expression. In particular, HMF induced Smad3 protein expression and suppressed Smad7 protein expression in UV-induced HDFn cells in a dose-dependent manner.
    CONCLUSIONS:
    These findings suggest a role for Citrusunshiu in the preparation of skincare products in future.
    J Agric Food Chem. 2008 Oct 22;56(20):9399-403.
    Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3',4',3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays.[Pubmed: 18816060 ]
    The anti-inflammatory properties of 3',4',3,5,6,7,8-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HMF), a citrus polymethoxylated flavone, were studied in the bacterial lipopolysaccharide (LPS)-challenge/tumor necrosis factor-alpha (TNFalpha) response in mice and in the carrageenan/paw edema assay in rats.
    METHODS AND RESULTS:
    In each of these trials, HMF administered by intraperitoneal (ip) injection exhibited anti-inflammatory activity, whereas HMF administered orally (po) produced no effects. The inhibition observed in the LPS-challenge/TNFalpha assay correlated with the HMF levels in the blood sera of mice dosed (ip) with either 33 or 100 mg/kg body weight. Low levels of HMF (0.035 +/- 0.024 ppm) were detected in the blood sera of mice dosed orally [100 mg of HMF (suspended in vegetable oil)/kg], whereas ip injection led to higher levels (0.517 +/- 0.051 ppm). This may account for the different levels of anti-inflammatory effects observed in mice following ip vs oral HMF administration. HMF metabolites, including a number of mono- and di-demethylated HMF metabolites and their glucuronic acid conjugates, were also detected, but results of these studies suggest that the glucuronidated metabolites of HMF are inactive in these inflammation models.
    Cancer Lett. 2001 Feb 10;163(1):7-9.
    Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.[Pubmed: 11163102]

    METHODS AND RESULTS:
    Nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HPT), isolated from the peel of Citrus plants, were examined for the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide, as an initiator and 12-O-tetradecanoylphorbol-13-acetate as a promoter.
    CONCLUSIONS:
    HPT exhibited the remarkable anti-tumor-initiating effect on mouse skin and it suggested the possibility of HPT being a chemopreventive agent against nitric oxide (NO) carcinogenesis.
    Neurochem Int. 2014 May;70:30-8.
    3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model.[Pubmed: 24657445 ]

    METHODS AND RESULTS:
    The present study evaluated the effects of treatment with the citrus flavonoid, 3,5,6,7,8,3',4'-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HMF) on protection against memory impairment and neuronal death in a global cerebral ischemia mouse model. The results showed that HMF, administrated for three days immediately after ischemic surgery, protected against ischemia-induced memory dysfunction, rescued neuronal cell death in the CA1 cell layer, increased the production of BDNF, stimulated the autophosphorylation of CaMK II and suppressed microglial activation in the hippocampus.
    CONCLUSIONS:
    These results suggest that HMF has a neuroprotective effect after brain ischemia by inducing BDNF production and anti-inflammatory effects.
    Biomed Res. 2016;37(2):95-9.
    3,5,6,7,8,3',4'-Heptamethoxyflavone reduces interleukin-4 production in the spleen cells of mice.[Pubmed: 27108879 ]
    In our previous studies, we reported anti-inflammatory functions of 3,5,6,7,8,3',4'-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HMF), which is a polymethoxyflavone rich in various citrus fruits.
    METHODS AND RESULTS:
    Here, we investigated the immunomodulatory function of HMF in mice. HMF administration (50 mg/kg, i.p., 2 times/week) tended to reduce the production of antigen-specific IgE induced by ovalbumin in combination with aluminum hydroxide gel. Fluorescence-activated cell sorting analysis revealed the reduction of interleukin-4(+)CD4(+) spleen cells and sustained presence of interferon-γ(+)CD4(+) spleen cells in mice administered HMF, whereas the ratio of CD4(+)CD8(-) versus CD4(-)CD8(+) spleen cells was not affected. Interleukin-4 release from CD3/CD28-stimulated spleen cells of mice administered HMF was reduced, whereas interferon-γ release was not affected.
    CONCLUSIONS:
    These results suggest that HMF has an immunomodulatory function via reduced interleukin-4 expression.
    2',4'-Dihydroxy-6'-methoxyacetophenone

    Catalog No: CFN98488
    CAS No: 3602-54-8
    Price: $100/5mg
    Nodakenetin

    Catalog No: CFN98788
    CAS No: 495-32-9
    Price: $268/10mg
    Jaceosidin

    Catalog No: CFN90386
    CAS No: 18085-97-7
    Price: $198/20mg
    Psoralenoside

    Catalog No: CFN92224
    CAS No: 905954-17-8
    Price: $338/5mg
    Isomucronulatol 7-O-glucoside

    Catalog No: CFN93256
    CAS No: 94367-43-8
    Price: $238/10mg
    Gelidoside

    Catalog No: CFN89019
    CAS No: 128420-44-0
    Price: $288/10mg
    Kobusin

    Catalog No: CFN89280
    CAS No: 36150-23-9
    Price: $318/10mg
    Poricoic acid G

    Catalog No: CFN95056
    CAS No: 415724-84-4
    Price: $318/5mg
    Bruceoside A

    Catalog No: CFN95080
    CAS No: 63306-30-9
    Price: $318/5mg
    8-Hydroxypinoresinol diglucoside

    Catalog No: CFN95083
    CAS No: 112747-99-6
    Price: $318/5mg