Product Name Phellamurin
CAS No.: 52589-11-4
Catalog No.: CFN98863
Molecular Formula: C26H30O11
Molecular Weight: 518.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: P-gp
Source: The barks of Phellodendron chinense Schneid.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to:

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Metabolites.2019, 9(11):E271
  • Front Cell Infect Microbiol.2018, 8:292
  • Sci Rep.2019, 9:12132
  • Preprints2017, 2017120176
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • J of L. Chroma.&Related Tech2017, 252-258
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Nat Commun.2019, 10(1):2745
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Pharmacol Rep.2019, 71(2):289-298
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    Planta Med. 2002 Feb;68(2):138-41.
    Marked decrease of cyclosporin absorption caused by phellamurin in rats.[Pubmed: 11859464]
    Phellamurin is a flavonoid glycoside that is abundant in the leaves of Phellodendron wilsonii Hayata et Kanehira (Rutaceae). In vitro everted rat intestine study indicated that Phellamurin inhibited intestinal P-glycoprotein in a dose-dependent manner.
    In order to investigate the effect of Phellamurin on cyclosporin absorption and disposition, rats were given cyclosporin (5 mg/kg) with or without Phellamurin in a parallel design. Fluorescence polarization immunoassay was used to determine the blood concentration of cyclosporin. Unanticipatedly, our results indicated that the coadministration of Phellamurin significantly decreased the Cmax of cyclosporin by 77 % and reduced the AUC(0-infinity) of cyclosporin by 56 %.
    This indicated that a serious interaction occurred between Phellamurin with cyclosporin. To ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.

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