Paeonilactone C
Paeonilactone C significantly protects primary cultures of rat cortical cells against H2O2-induced neurotoxicity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Sci Rep. 2017, 17332(7)
Comp. & Mathematical Methods in Med.2022, 5475559.
Nat Commun.2023 Dec 20;14(1):8457.
bioRxiv - Biochemistry2023, 541790.
Front Pharmacol.2018, 9:756
VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
FEMS Microbiol Lett.2017, 364(11)
J Cell Mol Med.2023, jcmm.18071.
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Antioxidants (Basel).2020, 9(4):326.
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J Enzyme Inhib Med Chem. 2009 Oct;24(5):1138-40.
Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro.[Pubmed:
19772486]
METHODS AND RESULTS:
The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H(2)O(2). Seven monoterpenes, paeonilactone-B (1), Paeonilactone C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques.
CONCLUSIONS:
Among them, compounds Paeonilactone C and 4 significantly protected primary cultures of rat cortical cells against H(2)O(2)-induced neurotoxicity.
