Galloylpaeoniflorin

Galloylpaeoniflorin
Product Name Galloylpaeoniflorin
CAS No.: 122965-41-7
Catalog No.: CFN90831
Molecular Formula: C30H32O15
Molecular Weight: 632.6 g/mol
Purity: >=98%
Type of Compound: Monoterpenoids
Physical Desc.: Powder
Targets: PAFR
Source: The roots of Paeonia lactiflora Pall.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $268/10mg
Galloylpaeoniflorin exhibits anticomplement effects, it reveals a more pronounced radical scavenging effect than a-tocopherol. Galloylpaeoniflorin can take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation. Galloylpaeoniflorin exhibits good activity on acute lung injury.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Phytother Res.2020, 34(4):788-795.
  • Int J Nanomedicine.2022, 17:6513-6525.
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Srinagarind Medical Journal2019, 34(1)
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • J Ethnopharmacol.2016, 192:370-381
  • J of Applied Biological Chem.2020, 63(2):147-152
  • Nutrients.2022, 14(19):4170.
  • Food Chem.2019, 275:746-753
  • Mol Microbiol.2019, 112(1):317-332
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    Galloylpaeoniflorin

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    CAS No: 122965-41-7
    Price: $268/10mg
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    Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4389-93.
    Spectrum-effect relationship of Moutan cortex against lipopolysaccharide-induced acute lung injury.[Pubmed: 25850273]
    This research is to study the relationship between HPLC fingerprints of Moutan Cortex, Paeoniae Radix Rubra and Paeoniae Radix Alba and their activity on lipopolysaccharide-induced acute lung injury. HPLC fingerprints of each extract of Moutan Cortex,Paeoniae Radix Rubra and Paeoniae Radix Alba were established by an optimized HPLC-MS method.
    METHODS AND RESULTS:
    The activities of all samples against protein and tumor necrosis a factor were tested by the model of lipopolysaccharide-induced acute lung injury. The possible relationship between HPLC-MS fingerprints and the activitieswere deduced by the Partial least squares regression analysis method. Samples were analyzed by HPLC-MS/MS to identify the major peaks. The results showed that each sample had some effect on acute lung injury. Four components with a lager contribution rate of efficacy were calculated by the research of spectrum-effect relationship.
    CONCLUSIONS:
    Moutan Cortex exhibited good activity on acute lung injury, and gallic acid, paeoniflorin, Galloylpaeoniflorin and paeonol were the main effective components.
    J Nat Prod. 2014 Jan 24;77(1):42-8.
    Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.[Pubmed: 24377852 ]
    Six new (1-6) and 19 known monoterpenoid glucosides were isolated from the root bark of Paeonia suffruticosa.
    METHODS AND RESULTS:
    The monoterpenoid glucosides 1, 2, 7, 10-19, and 22 exhibited anticomplement effects with CH50 and AP50 values ranging from 0.14 to 2.67 mM and 0.25 to 3.67 mM, respectively. In a mechanistic study, suffrupaeoniflorin A (1) interacted with C1q, C3, C5, and C9, while Galloylpaeoniflorin (12) and galloyloxypaeoniflorin (19) acted on C1q, C3, and C5 components in the complement activation cascade.
    Pharmazie. 2010 Aug;65(8):624-8.
    Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa.[Pubmed: 20824965]
    The roots of two Paeoniaceae family members have long been used as traditional medicines in Korea, China, and Japan. Dry roots of Paeonia lactiflora and dry root bark of P. suffruticosa are used under the traditional names of Paeoniae Radix and Moutan Cortex, respectively.
    METHODS AND RESULTS:
    Both Paeoniae Radix and Moutan Cortex have been used as remedies for cardiovascular diseases, for improving blood circulation, or for other uses. It was postulated that both plants may contain common active constituents that contribute to inhibiting blood coagulation and/or platelet aggregation. Eighteen compounds, which have been reported to be present in both plant medicines, were evaluated for their effects on platelet aggregation and blood coagulation. Paeonol (5), paeoniflorin (9), benzoylpaeoniflorin (11), and benzoyloxypaeoniflorin (12) were found to be the major common active constituents and they would collectively contribute to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation. In addition, methylgallate (4), (+)-catechin (7), paeoniflorigenone (8), Galloylpaeoniflorin (13), and daucosterol (16) may also take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation.
    Evid Based Complement Alternat Med . 2019 Mar 3;2019:6150357.
    The Screening Research of NF- κ B Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS[Pubmed: 30941197]
    Abstract Inflammation is a common and important pathological process, and nuclear factor-κB (NF-κB) is a key mediator of it. Moutan Cortex (MC), the dried root cortex of Paeonia suffruticosa Andr., is widely used as a remedy for the treatment of inflammatory diseases in Asian region. However, there are few studies on the systematic identification of NF-κB inhibitors of MC. In this study, the effect of inhibiting NF-κB activation of MC was assessed at the cellular level using a tumor necrosis factor-α (TNF-α) induced inflammatory model. Subsequently, ultra-performance liquid chromatography-quadrupole/time of flight-mass spectrometry (UPLC-Q/TOF-MS) combined with biological activity assay was established to screen and identify potential anti-inflammatory ingredients in MC. The results revealed that MC significantly inhibited the activation of NF-κB. Seven potential NF-κB inhibitors were screened from MC, including oxypaeoniflorin, paeoniflorin, Galloylpaeoniflorin, benzoyloxypaeoniflorin, mudanpioside C, gallic acid, and paeonol. Among them, the NF-κB inhibitor activity of Galloylpaeoniflorin, benzoyloxypaeoniflorin, and mudanpioside C is first reported here. In conclusion, the anti-inflammatory activity of MC was associated with the seven components mentioned above. And the bioactivity-integrated UPLC-Q/TOF which contains both chemical and bioactive details is suitable for screening active ingredients from natural medicines.
    Molecules. 2012 Apr 30;17(5):4915-23.
    Suffruyabiosides A and B, two new monoterpene diglycosides from moutan cortex.[Pubmed: 22547314 ]
    Suffruyabiosides A and B are rare monoterpene diglycosides, including a cellobiose in the molecules.
    METHODS AND RESULTS:
    Salicylpaeoniflorin (4) had a antiproliferation effect similar to paeoniflorin (3) on human lung adenocarcinoma epitherial A549 cells. Galloylpaeoniflorin (8) and salicylpaeoniflorin (4) revealed a more pronounced radical scavenging effect than a-tocopherol (positive control). An increase in the number of phenolic hydroxyl groups produced a more effective radical scavenging effect [8 > mudanpioside E (6) > oxypaeoniflorin (5)]. Comparison of the effects of 4 and 5 showed that o-substitution with a phenolic hydroxyl group was more effective than p-substitution.
    CONCLUSIONS:
    The results suggest that salicylpaeoniflorin (4) may be useful as a cytotoxic and a radical scavenging agent.
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