threo-Guaiacylglycerol-beta-coniferyl aldehyde ether

threo-Guaiacylglycerol-beta-coniferyl aldehyde ether
Product Name threo-Guaiacylglycerol-beta-coniferyl aldehyde ether
CAS No.: 650600-33-2
Catalog No.: CFN95417
Molecular Formula: C20H22O7
Molecular Weight: 374.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Leucaena leucocephala
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/5mg
the absolute configurations of guaiacylglycerol-β-coniferyl aldehyde ether had an impact on the inhibitory effect on Hep3B cells. The inactivation of MEK/ERK signaling pathway might contribute to apoptosis induction and ROS generation in guaiacylglycerol-β-coniferyl aldehyde ether-treated cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Anat Rec2018, 24264
  • Biomed Pharmacother.2022, 145:112474.
  • Antioxidants (Basel).2021, 10(10):1638.
  • J Ethnopharmacol.2017, 206:327-336
  • Int J Mol Sci.2020, 21(8):2790.
  • Food Sci Biotechnol.2024, 34(3):611-620.
  • Plants (Basel).2021, 10(5):951.
  • PLoS One.2018, 13(4):e0195642
  • Metabolites.2020, 10(11):440.
  • PLoS One.2017, 12(3):e0173585
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