Benzoylpaeoniflorin
Benzoylpaeoniflorin is active against cyclooxygenase(COX)-1 and COX-2 enzymes, it can restrain apoptosis of rats with coronary heart diseases by increasing the levels of Bc1-2 and decreasing the levels of Bax.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Effects of Benzoylpaeoniflorin on apoptosis of Rats with Coronary Heart Diseases.[Reference:
WebLink]
To Study the effects of Benzoylpaeoniflorin on apoptosis of rats with coronary heart diseases.
METHODS AND RESULTS:
Experimental rats model with coronary heart diseases caused by high fat foods were prepared and Benzoylpaeoniflorin were given for 4 weeks.Bc1-2、Bax in cardiac muscles of rats were detected with immunohistochemistry. Compared with that in normal group,Bc1-2 is lower and Bax is higher in model group(P0.05);After treatment,Bc1-2 increased and Bax decreased in treatment group.There is significant difference about Bc1-2 and Bax in treatment group and in model group(P0.05).But there is no great difference between treatment group and normal group(P0.05).
CONCLUSIONS:
Benzoylpaeoniflorin can restrain apoptosis of rats with coronary heart diseases by increasing the levels of Bc1-2 and decreasing the levels of Bax,suggesting that Benzoylpaeoniflorin may treat coronary heart disease by decreasing apoptosis.
Nat Prod Res. 2014;28(5):301-5.
New monoterpene glycosides from the root cortex of Paeonia suffruticosa and their potential anti-inflammatory activity.[Pubmed:
24236670]
METHODS AND RESULTS:
The methanol extract of the root cortex of Paeonia suffruticosa afforded two new monoterpene glycosides, paeoniside A (1) and paeoniside B (2), and three known monoterpene glycosides, paeoniflorin (3), Benzoylpaeoniflorin (4) and 4-O-methyl-paeoniflorin (5). Their structures were elucidated on the basis of spectroscopic means including 1D and 2D NMR experiments.
CONCLUSIONS:
Compounds 1-5 were found to be active against cyclooxygenase-1 and cyclooxygenase-2 enzymes.
J Pharm Biomed Anal. 2014 Sep;98:424-33.
Quantitative evaluation of Radix Paeoniae Alba sulfur-fumigated with different durations and purchased from herbal markets: simultaneous determination of twelve components belonging to three chemical types by improved high performance liquid chromatograph[Pubmed:
25011060]
METHODS AND RESULTS:
In this study, a improved high performance liquid chromatography-diode array detector (HPLC-DAD) method for simultaneous quantification of twelve major components belonging to three chemical types was developed and validated, and was applied to quantitatively compare the quality of Radix Paeoniae Alba (RPA) sulfur-fumigated with different durations and purchased from commercial herbal markets. The contents of paeoniflorin, Benzoylpaeoniflorin, oxypaeoniflorin, benzoic acid and paeonol decreased whereas that of paeoniflorin sulfonate increased in RPA with the extending of sulfur-fumigation duration. Different levels of paeoniflorin sulfonate were determined in ten of seventeen commercial RPA samples, indicating that these ten samples may be sulfur-fumigated with different durations. Moreover, the relative standard deviation of the contents of each component was higher in the commercial sulfur-fumigated RPA samples than that in commercial non-fumigated RPA samples, and the percentage of the total average content of monoterpene glycosides in the determined analytes was higher in the decoctions of commercial sulfur-fumigated RPA than that in commercial non-fumigated RPA samples.
CONCLUSIONS:
All these results suggested that the established method was precise, accurate and sensitive enough for the global quality evaluation of sulfur-fumigated RPA, and sulfur-fumigation can not only change the proportions of bioactive components, but also cause the reduction of the quality consistency of both raw materials and aqueous decoctions of RPA.
