Damulin A

Damulin A
Product Name Damulin A
CAS No.: 1202868-74-3
Catalog No.: CFN91838
Molecular Formula: C42H70O13
Molecular Weight: 783.0 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: AMPK
Source: The roots of Panax ginseng
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $413/5mg
Damulin A and Damulin B as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum, which may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Molecules.2017, 22(3)
  • Plant J.2017, 90(3):535-546
  • Spectrochim Acta A2019, 210:372-380
  • University of Limpopo2016, 1-237
  • Food Funct.2020, 10.1039
  • Int J Mol Sci.2019, 20(9):E2244
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Environ Toxicol.2019, 34(12):1354-1362
  • The Korea Society of Pha.2014, 300-314
  • Chemistr of plant2016, 2016021195
  • Ginsenoside Rk2

    Catalog No: CFN92818
    CAS No: 364779-14-6
    Price: $318/5mg
    Ginsenoside Rk1

    Catalog No: CFN92644
    CAS No: 494753-69-4
    Price: $188/20mg
    Ginsenoside Rh3

    Catalog No: CFN99972
    CAS No: 105558-26-7
    Price: $218/5mg
    Ginsenoside Rg5

    Catalog No: CFN92643
    CAS No: 186763-78-0
    Price: $168/10mg
    Damulin A

    Catalog No: CFN91838
    CAS No: 1202868-74-3
    Price: $413/5mg
    Damulin B

    Catalog No: CFN91837
    CAS No: 1202868-75-4
    Price: $413/5mg
    Ginsenoside Rk3

    Catalog No: CFN92593
    CAS No: 364779-15-7
    Price: $180/10mg
    Ginsenoside Rg6

    Catalog No: CFN90565
    CAS No: 147419-93-0
    Price: $318/5mg
    Ginsenoside Rh4

    Catalog No: CFN92594
    CAS No: 174721-08-5
    Price: $368/10mg
    Ginsenoside Rg4

    Catalog No: CFN90572
    CAS No: 126223-28-7
    Price: Inquiry(manager@chemfaces.com)
    Bioorganic & Medicinal Chemistry, 2011, 19(21):6254-6260.
    New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum.[Pubmed: 21978948]
    AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose, lipid, and energy metabolism throughout the body. Activation of AMPK improves metabolic abnormalities associated with metabolic diseases including obesity and type-2 diabetes. The oriental traditional medicinal herbal plant, Gynostemma pentaphyllum, has shown a wide range of beneficial effects on glucose and lipid metabolism.
    METHODS AND RESULTS:
    In this study, we found that G. pentaphyllum contains two novel dammarane-type saponins designated as Damulin A (1), 2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], and damulin B (2), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], that strongly activate AMPK in cultured L6 myotube cells. Damulin A and Damulin B also increased β-oxidation and glucose uptake with increasing GluT4 translocation to the plasma membrane in L6 myotube cells.
    CONCLUSIONS:
    Taken together our results indicate that activation of AMPK by Damulin A and Damulin B may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.
    Ganoderic acid C2

    Catalog No: CFN92054
    CAS No: 103773-62-2
    Price: $318/5mg
    Parishin A

    Catalog No: CFN93112
    CAS No: 62499-28-9
    Price: $120/20mg
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid

    Catalog No: CFN90804
    CAS No: 168293-13-8
    Price: $418/10mg
    Yadanzioside G

    Catalog No: CFN96422
    CAS No: 95258-17-6
    Price: $413/5mg
    Licoricone

    Catalog No: CFN96504
    CAS No: 51847-92-8
    Price: $333/5mg
    Epimedin K

    Catalog No: CFN95019
    CAS No: 174286-13-6
    Price: $288/5mg
    Momordicine II

    Catalog No: CFN95167
    CAS No: 91590-75-9
    Price: $318/10mg
    Yuanhunine

    Catalog No: CFN95179
    CAS No: 104387-15-7
    Price: $368/5mg
    Astin A

    Catalog No: CFN95187
    CAS No: 151201-75-1
    Price: $318/10mg
    Notoptol

    Catalog No: CFN95218
    CAS No: 88206-49-9
    Price: $318/5mg