Damulin B

Damulin B
Product Name Damulin B
CAS No.: 1202868-75-4
Catalog No.: CFN91837
Molecular Formula: C42H70O13
Molecular Weight: 783.0 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: AMPK
Source: The roots of Panax ginseng
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $413/5mg
Damulin A and Damulin B as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum, which may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Pharm Biomed Anal.2018, 151:32-41
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Cell Death Dis.2019, 10(12):882
  • Food Chem.2019, 275:746-753
  • Yakugaku Zasshi.2018, 138(4):571-579
  • J Ethnopharmacol.2019, 236:31-41
  • Oncotarget.2017, 8(53):90925-90947
  • Analytical methods2019, 11(6)
  • Food and Fermentation Industries2018, 44(371)
  • Drug Test Anal.2018, 10(10):1579-1589
  • Ginsenoside Rh4

    Catalog No: CFN92594
    CAS No: 174721-08-5
    Price: $368/10mg
    Ginsenoside Rg4

    Catalog No: CFN90572
    CAS No: 126223-28-7
    Price: Inquiry(manager@chemfaces.com)
    3-Acetoxy-24-hydroxydammara-20,25-diene

    Catalog No: CFN99477
    CAS No: 143519-04-4
    Price: Inquiry(manager@chemfaces.com)
    Ginsenoside Rk2

    Catalog No: CFN92818
    CAS No: 364779-14-6
    Price: $318/5mg
    Ginsenoside Rk1

    Catalog No: CFN92644
    CAS No: 494753-69-4
    Price: $188/20mg
    Ginsenoside Rh3

    Catalog No: CFN99972
    CAS No: 105558-26-7
    Price: $218/5mg
    Ginsenoside Rg5

    Catalog No: CFN92643
    CAS No: 186763-78-0
    Price: $168/10mg
    Damulin A

    Catalog No: CFN91838
    CAS No: 1202868-74-3
    Price: $413/5mg
    Damulin B

    Catalog No: CFN91837
    CAS No: 1202868-75-4
    Price: $413/5mg
    Ginsenoside Rk3

    Catalog No: CFN92593
    CAS No: 364779-15-7
    Price: $180/10mg
    Bioorganic & Medicinal Chemistry, 2011, 19(21):6254-6260.
    New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum.[Pubmed: 21978948]
    AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose, lipid, and energy metabolism throughout the body. Activation of AMPK improves metabolic abnormalities associated with metabolic diseases including obesity and type-2 diabetes. The oriental traditional medicinal herbal plant, Gynostemma pentaphyllum, has shown a wide range of beneficial effects on glucose and lipid metabolism.
    METHODS AND RESULTS:
    In this study, we found that G. pentaphyllum contains two novel dammarane-type saponins designated as damulin A (1), 2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], and Damulin B (2), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], that strongly activate AMPK in cultured L6 myotube cells. Damulin A and Damulin B also increased β-oxidation and glucose uptake with increasing GluT4 translocation to the plasma membrane in L6 myotube cells.
    CONCLUSIONS:
    Taken together our results indicate that activation of AMPK by Damulin A and Damulin B may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.
    Isoliquiritin

    Catalog No: CFN99155
    CAS No: 5041-81-6
    Price: $138/20mg
    Poncirin

    Catalog No: CFN90448
    CAS No: 14941-08-3
    Price: $218/20mg
    Hinokiflavone

    Catalog No: CFN92007
    CAS No: 19202-36-9
    Price: $318/10mg
    Ginsenoside Rk2

    Catalog No: CFN92818
    CAS No: 364779-14-6
    Price: $318/5mg
    Pyrocurzerenone

    Catalog No: CFN96169
    CAS No: 20013-75-6
    Price: $388/20mg
    6-Hydroxywogonin

    Catalog No: CFN95009
    CAS No: 76844-70-7
    Price: $368/5mg
    1-Methoxycarbonyl-beta-carboline-N-oxide

    Catalog No: CFN95023
    CAS No: 74690-74-7
    Price: $413/5mg
    3''-Galloylquercitrin

    Catalog No: CFN95048
    CAS No: 503446-90-0
    Price: $368/5mg
    Lonicerin

    Catalog No: CFN95055
    CAS No: 25694-72-8
    Price: $168/10mg
    Gardenin D

    Catalog No: CFN95133
    CAS No: 29202-00-4
    Price: $318/5mg