Bruceine B
Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysaccharide-stimulated HUVEC and T cell adhesion to TNF-stimulated HUVEC. Bruceine B exhibits potent anti-malarial activities with high selective toxicities; it also shows strong antitrypanosomal activities with IC(50) values in the range of 2.9-17.8nM. Bruceine B shows strong antiviral activities, with IC(50) values in the range of 3.42-5.66 microM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Agric Food Chem. 2010 Feb 10;58(3):1572-7.
Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr.[Pubmed:
20050684 ]
Two new quassinoids, javanicolide E (1) and javanicolide F (2), along with fifteen known C-20 quassinoids were isolated from the seeds of Brucea javanica (L.) Merr.
METHODS AND RESULTS:
The antitobacco mosaic virus (TMV) activity of these quassinoids was screened by the conventional half-leaf and leaf-disk method along with Western blot analysis. All of the seventeen quassinoids showed potent anti-TMV activity.
CONCLUSIONS:
Among them, eight compounds, brusatol (3), Bruceine B (4), bruceoside B (5), yadanzioside I (6), yadanzioside L (7), bruceine D (8), yadanziolide A (9), and aglycone of yadanziolide D (17), showed strong antiviral activities, with IC(50) values in the range of 3.42-5.66 microM, and were much more effective than the positive control, ningnanmycin (IC(50) = 117.3 microM).
The antiviral structure-activity relationships of quassinoids against TMV were also discussed.
Vet Parasitol. 2008 Dec 20;158(4):288-94.
In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica.[Pubmed:
18986767 ]
The medicinal plant Brucea javanica (L.) Merr. (Simaroubaceae) is widely distributed throughout Asia where its bitter fruits have been used in traditional medicine for various ailments.
METHODS AND RESULTS:
Fifteen C-20 quassinoids were isolated from the fruits of B. javanica and examined for their in vitro antitrypanosomal activities against trypomastigotes of Trypanosoma evansi. Bruceine A, bruceantinol, bruceine C, brusatol, and Bruceine B showed strong antitrypanosomal activities with IC(50) values in the range of 2.9-17.8nM, which compared well with the standard trypanocidal drugs diminazene aceturate (IC(50)=8.8nM) and suramin (IC(50)=43.2nM). However, dehydrobruceine A, dehydroBruceine B, and dehydrobrusatol were about 2100, 900, and 1200 times less active, respectively, than bruceine A, Bruceine B, and brusatol.
CONCLUSIONS:
The relationship of the structure and antitrypanosomal activity of these quassinoid compounds suggested that the presence of a diosphenol moiety in ring A and the nature of the C-15 side chain are important for their activities against T. evansi. This is the first report on the antitrypanosomal activity of isolated quassinoids.
Bioorg Med Chem Lett. 1998 Mar 3;8(5):459-62.
Anti-malarial activities of acylated bruceolide derivatives.[Pubmed:
9871598]
METHODS AND RESULTS:
Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined.
CONCLUSIONS:
It was found that 3,15-di-O-acetyl-(3c), 3,15-di-O-propionyl-(3d) and 15-O-propionylbruceolide (3b), as well as Bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.
Inflammation. 1997 Apr;21(2):223-33.
Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion.[Pubmed:
9187964]
Leukocyte adhesion to vascular endothelial cells is an essential step in the development of inflammatory diseases.
METHODS AND RESULTS:
We have searched for inhibitors of leukocyte-endothelial cell adhesion that could be used as anti-inflammatory drugs and found that Bruceine B (0.2 microgram/ml; 0.44 microM) inhibited human neutrophil or T cell adhesion to tumor necrosis factor-alpha (TNF) stimulated human umbilical vein endothelial cells (HUVEC). The inhibition of neutrophil adhesion to TNF-stimulated HUVEC by Bruceine B was not derived from cytotoxic effects, as determined by measurement of the level of lactate dehydrogenase (LDH) activity in conditioned medium.
The effect of Bruceine B on neutrophil adhesion to HUVEC was not seen when the neutrophils were preincubated with Bruceine B. However, inhibitory effects were evident when the HUVEC were preincubated with Bruceine B. Bruceine B also inhibited neutrophil adhesion to lipopolysaccharide-stimulated HUVEC and T cell adhesion to TNF-stimulated HUVEC.
CONCLUSIONS:
These findings suggest that Bruceine B may have anti-inflammatory activity.
Arch Pharm Res. 2011 Aug;34(8):1297-300.
One new pregnane glycoside from the seeds of cultivated Brucea javanica.[Pubmed:
21910051 ]
METHODS AND RESULTS:
A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), Bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica. The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested.
Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells.
CONCLUSIONS:
These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.
