Bruceine E

Bruceine E
Product Name Bruceine E
CAS No.: 21586-90-3
Catalog No.: CFN89340
Molecular Formula: C20H28O9
Molecular Weight: 412.43 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The seeds of Brucea javanica (L.) Merr.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $138/20mg
Bruceine E exhibits significant blood glucose concentration reduction activity, it might act as an insulin secretagogue.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • Cosmetics2021, 8(3),91.
  • Preprints2017, 2017120176
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • Industrial Crops and Products2022, 186:115298
  • Biomedicines.2021, 9(8):996.
  • Drug Des Devel Ther.2020, 14:969-976.
  • Planta Med.2022, a-1876-3009.
  • Food Chem.2017, 221:1135-1144
  • Brusatol

    Catalog No: CFN93119
    CAS No: 14907-98-3
    Price: $168/20mg
    Bruceantin

    Catalog No: CFN89339
    CAS No: 41451-75-6
    Price: $413/5mg
    Bruceanic acid C

    Catalog No: CFN91975
    CAS No: 132587-60-1
    Price: Inquiry(manager@chemfaces.com)
    Ailanthone

    Catalog No: CFN97561
    CAS No: 981-15-7
    Price: $318/20mg
    Etuycomanol

    Catalog No: CFN95771
    CAS No: 84633-28-3
    Price: $318/10mg
    Eurycomanone

    Catalog No: CFN92008
    CAS No: 84633-29-4
    Price: $268/20mg
    13beta,21-dihydroxyeurycomanone (Pasakbumin C)

    Catalog No: CFN95770
    CAS No: 129587-06-0
    Price: $318/10mg
    Pasakbumin B

    Catalog No: CFN92009
    CAS No: 138809-10-6
    Price: Inquiry(manager@chemfaces.com)
    Bruceine D

    Catalog No: CFN90771
    CAS No: 21499-66-1
    Price: $138/20mg
    Yadanziolide C

    Catalog No: CFN96426
    CAS No: 95258-12-1
    Price: Inquiry(manager@chemfaces.com)
    Arch Pharm Res. 2011 Aug;34(8):1297-300.
    One new pregnane glycoside from the seeds of cultivated Brucea javanica.[Pubmed: 21910051]
    A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), Bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica.
    METHODS AND RESULTS:
    The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells.
    CONCLUSIONS:
    These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.
    J Ethnopharmacol. 2009 Jul 30;124(3):586-91.
    Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds.[Pubmed: 19439174 ]
    The seeds of Brucea javanica (L.) Merr (Simaroubaceae) are recommended by traditional practitioners for the treatment of diabetes mellitus. To identify the compounds responsible for blood glucose lowering effect and evaluate the acute toxicity of the compounds.
    METHODS AND RESULTS:
    Extracts, fractions and subfractions were administered to normoglycemic mice and the blood glucose concentration was monitored for 8 h. Bioactive compounds isolated through column chromatography were administered to normoglycemic mice and streptozotocin (STZ) rats with monitoring of blood glucose concentration at 0-8h. The acute toxicity was evaluated in mice. Bioactivity-guided fractionation led to the isolation of Bruceine E (1) and bruceine D (2). Normoglycemic mice administered with 1 mg/kg of 1 and 2 exhibited significant blood glucose concentration reduction of 40.07+/-11.45% and 48.82+/-13.34%, respectively. STZ induced diabetic rats administered with 1 and 2 exhibited significant blood glucose concentration reduction of 73.57+/-13.64% and 87.99+/-2.91%, respectively.
    CONCLUSIONS:
    The reduction of blood glucose concentration by both bruceines was comparable to glibenclamide and they might act as an insulin secretagogue. The presence of a hydroxyl moiety at C(2) in 1 reduced the toxic effect by 9-fold compared to 2.
    Rhamnetin 3-galactoside

    Catalog No: CFN95116
    CAS No: 62858-07-5
    Price: $318/10mg
    N-Methylcorydalmine

    Catalog No: CFN95204
    CAS No: 81010-29-9
    Price: $398/5mg
    Cannabisin B

    Catalog No: CFN95268
    CAS No: 144506-17-2
    Price: $413/5mg
    Isomargaritene

    Catalog No: CFN95304
    CAS No: 64271-11-0
    Price: $318/10mg
    trans-Psoralenoside

    Catalog No: CFN95349
    CAS No: N/A
    Price: $318/5mg
    New compound 11

    Catalog No: CFN95351
    CAS No: N/A
    Price: $318/10mg
    New compound 15

    Catalog No: CFN95413
    CAS No: N/A
    Price: $413/5mg
    Isosecotanapartholide

    Catalog No: CFN95471
    CAS No: 102926-01-2
    Price: $318/10mg
    Peltatoside 7-O-beta-glucopyranoside

    Catalog No: CFN95565
    CAS No: 813466-12-5
    Price: $318/20mg
    N-Methyldehydrococlaurine

    Catalog No: CFN95588
    CAS No: N/A
    Price: $318/5mg