Yadanziolide B
Yadanziolide B exhibits cytotoxic activities with IC50 values of 3.00-5.81 uM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Nat Prod. 2011 Nov 28;74(11):2438-45.
Indole alkaloids and quassinoids from the stems of Brucea mollis.[Pubmed:
22070654]
METHODS AND RESULTS:
Seven new indole alkaloids, bruceollines H-N (1-7), three new quassinoids, yadanziolides T-V (10-12), and four known analogues, bruceolline E (8), bruceolline F (9), bruceine D (13), and Yadanziolide B (14), were isolated from an ethanol extract of the stems of Brucea mollis.
CONCLUSIONS:
The absolute configurations of compounds 2 and 5 were determined by comparison of their experimental and calculated ECD spectra.
The absolute configuration of the known compound 9 was determined by using Mo2(OAc)4-induced CD analysis for the first time. Compounds 10, 13, and 14 exhibited cytotoxic activities with IC50 values of 3.00-5.81 μM.
Chemical & Pharmaceutical Bulletin, 1984 , 32 (11) :4698-701.
Structures of yadanziolides A, B, and C, new bitter principles from Brucea javanica.[Reference:
WebLink]
Three bitter quassinoids, yadanziolide A, Yadanziolide B, and yadanziolide C (1, 2 and 3), were isolated from seeds of Brucea javanica, known as"Ya-dan-zi" in Chinese folklore and their structures have been established from chemical transformation and spectral analysis.
