Bruceantinol

Bruceantinol
Product Name Bruceantinol
CAS No.: 53729-52-5
Catalog No.: CFN89336
Molecular Formula: C30H38O13
Molecular Weight: 606.62 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Targets: Antifection
Source: The fruits of Brucea javanica (L.) Merr.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Bruceantinol has antiviral activity, it can inhibit pepper mottle virus in pepper; it shows antibabesial activity against Babesia gibsoni in vitro, with the IC50 value of 12 ng/mL. Bruceantinol shows in vitro inhibitory activity against Trypanosoma evansi.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Mol Pharm.2017, 14(9):3164-3177
  • Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
  • J Nat Med.2018, 72(3):734-744
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • J Inflamm Res.2022, 15:5347-5359.
  • Natural Product Sciences2024, 30(1):8-13.
  • Oncol Rep.2016, 35(3):1356-64
  • Molecules.2018, 23(9):E2121
  • Nutrients.2018, 10(12)
  • Evid Based Complement Alternat Med.2022, 2022:3483511
  • Bruceine J

    Catalog No: CFN91973
    CAS No: 948038-38-8
    Price: Inquiry(manager@chemfaces.com)
    Bruceine A

    Catalog No: CFN89338
    CAS No: 25514-31-2
    Price: Inquiry(manager@chemfaces.com)
    Brusatol

    Catalog No: CFN93119
    CAS No: 14907-98-3
    Price: $168/20mg
    Bruceantin

    Catalog No: CFN89339
    CAS No: 41451-75-6
    Price: $413/5mg
    Bruceanic acid C

    Catalog No: CFN91975
    CAS No: 132587-60-1
    Price: Inquiry(manager@chemfaces.com)
    Ailanthone

    Catalog No: CFN97561
    CAS No: 981-15-7
    Price: $318/20mg
    Etuycomanol

    Catalog No: CFN95771
    CAS No: 84633-28-3
    Price: $318/10mg
    Eurycomanone

    Catalog No: CFN92008
    CAS No: 84633-29-4
    Price: $268/20mg
    13beta,21-dihydroxyeurycomanone (Pasakbumin C)

    Catalog No: CFN95770
    CAS No: 129587-06-0
    Price: $318/10mg
    Pasakbumin B

    Catalog No: CFN92009
    CAS No: 138809-10-6
    Price: Inquiry(manager@chemfaces.com)
    Virus Res. 2017 Jan 2;227:49-56.
    Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper.[Pubmed: 27686478 ]

    METHODS AND RESULTS:
    A green fluorescent protein (GFP)-tagged pepper mottle virus (PepMoV) based leaf-disc method and systemic host method were developed to identify antiviral agents. Preliminary experiments using a PepMoV-GFP based leaf-disc method led to the isolation of five quassinoids, including brusatol (1), bruceantin (2), brucein A (3), Bruceantinol (4), and brucein B (5), from the CH3OH extract of Brucea javanica.
    CONCLUSIONS:
    All isolated compounds exhibited inactivation effects in systemic host plants, and compounds 3 and 4 were potent, with a minimum inhibitory concentration of 10μM. Furthermore, compound 3 was found to have a protective effect at the tested concentration of 40μM.
    J Nat Prod. 2007 Oct;70(10):1654-7.
    Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica.[Pubmed: 17896817]
    Boiled extracts derived from 28 Indonesian medicinal plants were screened for their antibabesial activity against Babesia gibsoni in vitro.
    METHODS AND RESULTS:
    Of these extracts, the fruit of Brucea javanica was the most active in inhibiting parasite growth at a concentration of 10 microg/mL. Bioassay-guided fractionation of the fruit extract of Br. javanica led to the isolation of two new quassinoids, Bruceantinol B and bruceine J, and the structures of these compounds were elucidated on the basis of their spectroscopic data and by chemical transformation to known compounds. In addition, the known quassinoids bruceines A-D, Bruceantinol, and yadanziolide A were isolated.
    CONCLUSIONS:
    Antibabesial activities were also examined in vitro, and bruceine A and Bruceantinol were shown to be more potent than diminazene aceturate, a drug (IC50 = 103 ng/mL) used clinically against B. gibsoni, with IC50 values of 4 and 12 ng/mL, respectively.
    J Nat Med. 2012 Jan;66(1):233-40.
    Antitrypanosomal activities of acetylated bruceines A and C; a structure-activity relationship study.[Pubmed: 21822605]

    METHODS AND RESULTS:
    The crude extract of Brucea javanica showed strong in vitro inhibitory activity against Trypanosoma evansi. Among the isolated quassinoids, bruceines A, C, and Bruceantinol were found to be the most potent compounds against T. evansi. To gain a deeper understanding of the relationship between the free hydroxyl groups and the activity, several O-acetylated derivatives of bruceines A and C were synthesized and their in vitro antitrypanosomal activities against trypomastigotes of T. evansi were examined and compared with those of the original compounds.
    CONCLUSIONS:
    The following structure-activity relationships were observed: (1) the free hydroxyl groups at positions C-3, C-11, and C-12 are essential for antitrypanosomal activity; (2) the C-11 and C-12 hydroxyl groups are more important for the activity than the enolic hydroxyl group at C-3, and; (3) the free hydroxyl group at C-4' of bruceine C does not have any significant effect on the activity.
    Suspenoidside B

    Catalog No: CFN95071
    CAS No: 2161432-08-0
    Price: $413/5mg
    Isorubrofusarin 10-gentiobioside

    Catalog No: CFN95119
    CAS No: 200127-93-1
    Price: $338/10mg
    5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)

    Catalog No: CFN95135
    CAS No: 79559-61-8
    Price: $268/20mg
    Orientalide

    Catalog No: CFN95136
    CAS No: 72704-05-3
    Price: $368/5mg
    Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside

    Catalog No: CFN95157
    CAS No: 1147858-78-3
    Price: $318/10mg
    Isonardosinone

    Catalog No: CFN95180
    CAS No: 27062-01-7
    Price: $318/10mg
    Vaccarin E

    Catalog No: CFN95252
    CAS No: 2252345-81-4
    Price: $318/10mg
    Margaritene

    Catalog No: CFN95303
    CAS No: 64271-10-9
    Price: $318/10mg
    4-Methoxybenzoylacetic acid

    Catalog No: CFN95446
    CAS No: 13422-77-0
    Price: $318/5mg
    1-O-Feruloylglucose

    Catalog No: CFN95596
    CAS No: 64625-37-2
    Price: $413/5mg