13,18-Dehydroglaucarubinone
13,18-Dehydroglaucarubinone can inhibit growth of the murine lymphocytic leukemia P388.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Chung Shan Medical University2020, US20200323790A1
Chinese Pharmacological Bulletin2019, 35(8):1120-1125
Univerzita Karlova2022, 228192.
Phytother Res.2022, 10.1002:ptr.7626.
Molecules 2022, 27(3),1047.
J Med Chem.2023, 66(6):4106-4130.
Molecules.2023, 28(9):3685.
The Japan Society for Analytical Chemistry2018, 67(4):201-206
Foods.2022, 11(12):1773.
Pharmacognosy Journal.2020, 12(2), p232-235.
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Experientia. 1978 Sep 15;34(9):1122-3.
The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara.[Pubmed:
720499]
METHODS AND RESULTS:
An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2'-acetylglaucarubine (1a) and 13,18-Dehydroglaucarubinone (2). The previously known 2'-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained.
CONCLUSIONS:
The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.
