Epischisandrone

Pharm Biol. 2013 Sep;51(9):1204-7.

Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens.[Pubmed: 23883077 ]

The diethyl ether extract of the stems of Schisandra pubescens Hemsl. et Wils. (Schisandraceae) was found to exhibit cytotoxic activity in vitro. However, investigations of the bioactive constituents of this plant have been very limited. Elucidation of the cytotoxic constituents of S. pubescens was performed.
METHODS AND RESULTS:
Repeated silica gel column chromatography and preparative TLC were used for the chemical investigation of the diethyl ether extract of S. pubescens stems. All isolates were evaluated for their in vitro cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines.Nine known compounds were obtained, including four lignans, Epischisandrone (1), tigloylgomisin P (2), cagayanone (3) and (-)-gomisin L₂ (4), together with five triterpenoids, micranoic acid B (5), lancifodilactone H (6), coccinic acid (7), schisanlactone B (8) and anwuweizonic acid (9). Compounds 2-6 and 8 showed moderate to marginal cytotoxicity, with GI₅₀ values of 11.83-35.65 μM.
CONCLUSIONS:
The isolation of 1-9 from S. pubescens and the cytotoxicities of 3-6 are first reported. Compounds 2-6 and 8 could be the active principles responsible for the anticancer effects of S. pubescens.

Chem Pharm Bull (Tokyo). 2009 Apr;57(4):405-7.

Two new lignans from Schisandra henryi.[Pubmed: 19336937]

METHODS AND RESULTS:
Two new lignans, henricines A (1) and B (2), were isolated along with the eight known lignans, ganshisandrine (3), wulignan A(2) (4), epiwulignan A(1) (5), deoxyschisandrin (6), wulignan A(1) (7), Epischisandrone (8), schisantherin A (9), and schisandrol A (10), from the stems of Schisandra henryi.
CONCLUSIONS:
The structures of the new compounds were elucidated based on the spectral analysis, including 1D and 2D NMR experiments.