Epimedin B1

Epimedin B1
Product Name Epimedin B1
CAS No.: 133137-58-3
Catalog No.: CFN95017
Molecular Formula: C38H48O19
Molecular Weight: 808.8 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow Powder
Source: The herbs of Epimedium sagittatum
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $268/5mg
Reference standards.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Molecules.2017, 22(12)
  • Industrial Crops and Products2020, 146:112186
  • Phytochem Anal.2013, 24(5):493-503
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Universidade Estadual Paulista2017, 42785
  • Nat Commun.2019, 10(1):2745
  • Int J Mol Sci.2019, 20(23):E6071
  • US20170000760 A12016, 42740
  • PLoS One.2018, 13(3):e0193386
  • Int J Pharmacol2020, 16:1-9
  • Iso-sagittatoside A

    Catalog No: CFN91155
    CAS No: 503456-08-4
    Price: $318/5mg
    Korepimedoside A

    Catalog No: CFN92905
    CAS No: 106441-31-0
    Price: Inquiry(manager@chemfaces.com)
    Baohuoside VII

    Catalog No: CFN90765
    CAS No: 119730-89-1
    Price: $538/10mg
    Icariin

    Catalog No: CFN99554
    CAS No: 489-32-7
    Price: $30/20mg
    Epimedin B

    Catalog No: CFN99940
    CAS No: 110623-73-9
    Price: $128/20mg
    Epimedin B1

    Catalog No: CFN95017
    CAS No: 133137-58-3
    Price: $268/5mg
    Maohuoside B

    Catalog No: CFN91887
    CAS No: 849834-04-4
    Price: Inquiry(manager@chemfaces.com)
    Epimedin C

    Catalog No: CFN99941
    CAS No: 110642-44-9
    Price: $100/20mg
    Epimedin A1

    Catalog No: CFN99145
    CAS No: 140147-77-9
    Price: $238/20mg
    Epimedin A

    Catalog No: CFN99939
    CAS No: 110623-72-8
    Price: $128/20mg
    Molecules, 2014, 19(1):686-698.
    Study on the Mechanism of Intestinal Absorption of Epimedins A, B and C in the Caco-2 Cell Model.[Reference: WebLink]
    Epimedium spp. is commonly used in Traditional Chinese Medicine. Epimedin A, Epimedin B(Epimedin B1 ), and Epimedin C are three major bioactive flavonoids found in Epimedium spp. that share similar chemical structures.
    METHODS AND RESULTS:
    In this study, the intestinal absorption mechanism of these three compounds was investigated using the Caco-2 cell monolayer model in both the apical-to-basolateral (A-B) and the basolateral-to-apical (B-A) direction. The absorption permeability (PAB) of epimedin A, epimedin B0, and epimedin C were extremely low and increased as the concentration of the epimedins increased from 5 to 20 μM, but, at 40 μM, the PAB values were reduced. Meanwhile, the amount of transported compounds increased in a time-dependent manner. The PAB of epimedins A and C were significantly increased and efflux ratios decreased in the presence of verapamil (an inhibitor of P-glycoprotein) and dipyridamole (an inhibitor of breast cancer resistance protein) while, in the presence of MK571 (an inhibitor of multidrug resistance proteins), the absorption of epimedins A and C did not change significantly, indicating that P-gp and BCRP might be involved in the transport of epimedins A and C. The PAB of epimedin B significantly increased while its secretory permeability (PBA) significantly decreased in the presence of dipyridamole, indicating that BCRP might be involved in the transport of epimedin B. No obvious changes in the transport of epimedin B were observed in the presence of verapamil and MK571.
    CONCLUSIONS:
    In summary, our results clearly demonstrate, for the first time, that poor bioavailability of these three prenylated flavonoids is the result of poor intrinsic permeability and efflux by apical efflux transporters.
    Agnuside

    Catalog No: CFN99203
    CAS No: 11027-63-7
    Price: $158/10mg
    Feretoside

    Catalog No: CFN98330
    CAS No: 27530-67-2
    Price: $366/10mg
    1-Methoxycarbonyl-beta-carboline

    Catalog No: CFN98456
    CAS No: 3464-66-2
    Price: $288/5mg
    Acetylshikonin

    Catalog No: CFN90308
    CAS No: 54984-93-9
    Price: $418/20mg
    11-Hydroxycanthin-6-one

    Catalog No: CFN92125
    CAS No: 75969-83-4
    Price: $413/5mg
    Pallidol

    Catalog No: CFN92341
    CAS No: 105037-88-5
    Price: $318/10mg
    Dehydrotrametenolic acid

    Catalog No: CFN90577
    CAS No: 29220-16-4
    Price: $268/20mg
    Hypaphorine

    Catalog No: CFN90634
    CAS No: 487-58-1
    Price: $198/20mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $218/20mg
    (-)-Epiafzelechin 3-O-gallate

    Catalog No: CFN95081
    CAS No: 108907-43-3
    Price: $388/5mg