Hot Products

Dihydrorotenone
Catalog No: CFN90585

Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. It induces human plasma cell apoptosis by provoking endoplasmic reticulum stress and induces cell death by activating the p38 but not the JNK signaling pathway.

Dihydrosanguinarine
Catalog No: CFN92810

Dihydrosanguinarine has antifungal and anticancer activity.Dihydrosanguinarine at concentrations from 5 microM induced primarily necrosis, whereas apoptosis occurred at 10 microM and above. Dihydrosanguinarine has potential application in the therapy of serious infection caused by I. multifiliis.

Dihydrotamarixetin
Catalog No: CFN97194

Reference standards.

Dihydrotanshinone I
Catalog No: CFN97435

Dihydrotanshinone I is a potent inhibitor of the HuR:RNA interaction, it exhibits strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation, and UDP-glucuronosyltransferase (UGT) 1A7. Dihydrotanshinone I has antibacterial, anti-cancer, anti-angiogenic, and cytotoxic activities, it induces caspase and ROS dependent apoptosis and autophagy.

Dihydrowithaferin A
Catalog No: CFN91055

2, 3-Dihydrowithaferin A in the diet may prevent or decrease the growth of tumors in human.

Dihydroxyfumaric acid
Catalog No: CFN70059

Dihydroxyfumaric acid can induce lipid peroxidation in rat liver microsomes.

Diisobutyl phthalate
Catalog No: CFN96846

Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis. Diisobutyl phthalate administered by gavage is embryotoxic and teratogenic, and affects the developing male reproductive tract, at maternal toxic doses. Diisobutyl phthalate could through blood-brain barrier after oral intake, and disordered the way of apoptosis of hippocampal cells, and morphologic change of mitochondria mybe is the main reason of changes of neuron apoptosis; it induced oxidative stress, which can decrease the activities of antioxidative enzymes and result in oxidative damage of tissues.

Dimeric coniferyl acetate
Catalog No: CFN99853

Dimeric coniferyl acetate has anti-inflammary activity, it shows strong NO inhibition with IC50 values of 27.1 uM in lipopolysacchalide (LPS)-activated murine macrophage-like J774.1 cells. It exhibits significant inhibitory effects on the nitric oxide production in lipopolysaccharide activated C57BL6/J mouse macrophages.

Dimethyl lithospermate B
Catalog No: CFN90690

Dimethyl lithospermate B is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action.Dimethyl lithospermate B slows inactivation of INa, leading to increased inward current during the early phases of the action potential (AP), might be an excellent candidate for a Na(+) channel agonist; it is effective in eliminating the arrhythmogenic substrate responsible for the Brugada syndrome and that it deserves further study as a pharmacological adjunct to implanted cardioverter/defibrillator usage.

Dimethylacrylshikonin
Catalog No: CFN90164

Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors, it inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway. Dimethylacrylshikonin inhibits agonist-induced relaxation at lower concentrations and induces vasocontraction at higher concentrations.