Soyacerebroside I
Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity. Soyacerebroside I shows anti-inflammatory activity, it can inhibit the accumulation of pro-inflammatory iNOS protein and reduce the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophages. Soyacerebrosides I and II have modulating the cellular immune response effects, they show obvious inhibitory activity on IL-18 secretion in human peripheral blood mononuclear cells (PBMC).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chem Pharm Bull (Tokyo). 2004 Oct;52(10):1235-7.
A new phenanthrene glycoside and other constituents from Dioscorea opposita.[Pubmed:
15467243]
METHODS AND RESULTS:
Phytochemical investigation of the rhizome of Dioscorea opposita has led to the isolation of a new phenanthrene glycoside, 3,4,6-trihydroxyphenanthrene-3-O-beta-D-glucopyranoside (1), and five known compounds, Soyacerebroside I (2), adenosine (3), beta-sitosterol (4), palmitic acid (5) and palmitoyloleoylphosphatidylcholine (6). Their structures were determined by spectroscopic methods, including 1D- and 2D-NMR.
CONCLUSIONS:
Compounds 1-6 exhibited no antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis.
Arch Pharm Res. 2008 May;31(5):579-86.
Cytotoxic constituents of Amanita subjunquillea.[Pubmed:
18481012]
As part of our systematic study of Korean toxic mushrooms, we have investigated the constituents of Amanita subjunquillea.
METHODS AND RESULTS:
The column chromatographic separation of the MeOH extract of A. subjunquillea led to the isolation of four ergosterols, two cerebrosides and four cyclopeptides. Their structures were determined by spectroscopic methods to be (22E,24R)-5alpha,8alpha-epidioxyergosta-6,9,22-triene-3beta-ol (1), (22E,24R)-5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (2), (22E,24R)-5alpha,6alpha-epoxyergosta-8,22-diene-3beta,7beta-diol (3), (24S)-ergost-7-en-3beta-ol (4), 8,9-dihydroSoyacerebroside I (5), Soyacerebroside I (6), beta-amanitin (7), phalloin (8), alpha-amanitin (9), and phalloidin (10). The compounds 1-6 and 8 were isolated for the first time from this mushroom.
The isolated compounds were evaluated for the cytotoxicity against A549, SK-OV-3, SK-MEL-2 and HCT15 cells.
CONCLUSIONS:
Compound 9 exhibited significant cytotoxic activity against A549, SK-OV-3, SK-MEL-2 and HCT15 with ED(50) values of 1.47, 0.26, 1.57 and 1.32 microM, respectively.
J Agric Food Chem. 2016 Feb 24;64(7):1540-8.
Anti-inflammatory Cerebrosides from Cultivated Cordyceps militaris.[Pubmed:
26853111]
Cordyceps militaris (bei-chong-chaw, northern worm grass) is a precious and edible entomopathogenic fungus, which is widely used in traditional Chinese medicine (TCM) as a general booster for the nervous system, metabolism, and immunity. Saccharides, nucleosides, mannitol, and sterols were isolated from this fungus. The biological activity of C. militaris was attributed to the saccharide and nucleoside contents.
METHODS AND RESULTS:
In this study, the aqueous methanolic fraction of C. militaris fruiting bodies exhibited a significant anti-inflammatory activity. Bioactivity-guided fractionation of the active fraction led to the isolation of eight compounds, including one new and two known cerebrosides (ceramide derivatives), two nucleosides, and three sterols.
CONCLUSIONS:
Cordycerebroside A (1), the new cerebroside, along with Soyacerebroside I (2) and glucocerebroside (3) inhibited the accumulation of pro-inflammatory iNOS protein and reduced the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophages. This is the first study on the isolation of cerebrosides with anti-inflammatory activity from this TCM.
Planta Med. 2008 Jan;74(1):55-60.
Tyrosinase inhibitors and sesquiterpene diglycosides from Guioa villosa.[Pubmed:
18203056]
METHODS AND RESULTS:
Through a bioassay-guided phytochemical investigation involving mushroom tyrosinase inhibitory activity, seven farnesyl diglycosides ( 1 - 7), five flavonoids ( 8 - 12), one trimeric proanthocyanidin ( 13), two triterpenes ( 14 and 15), and one cerebroside ( 16), were isolated from the leaves of Caledonian Guioa villosa. Among them, crenulatosides E, F and G ( 1 - 3) were new acyclic sesquiterpene diglycosides.
CONCLUSIONS:
The sesquiterpene diglycosides isolated from the active EtOAc extract showed no inhibitory activity, whereas betulin ( 14), lupeol ( 15) and Soyacerebroside I ( 16) demonstrated a potent tyrosinase inhibitory activity.
Lipids. 2009 Aug;44(8):759-63.
An isomeric mixture of novel cerebrosides isolated from Impatiens pritzellii reduces lipopolysaccharide-induced release of IL-18 from human peripheral blood mononuclear cells.[Pubmed:
19609788 ]
An isomeric mixture of two cerebrosides, Soyacerebroside I and Soyacerebroside II, was isolated from an ethno drug, the rhizomes of Impatiens pritzellii Hook. f. var. hupehensis Hook. f., and their structures were identified by spectroscopic (NMR, MS) analysis.
METHODS AND RESULTS:
In order to determine the immunomodulatory activities of soya-cerebrosides I and II, the effects of the mixture of cerebrosides (MC) on cytotoxicity of human peripheral blood mononuclear cells (PBMC) and the inhibitory activities to lipopolysaccharide (LPS)-induced interleukin (IL)-18 in PBMC were studied. The MC at concentrations of 10 and 1 microM, without toxicity to PBMC in 24 h, showed obvious inhibitory activity on IL-18 secretion.
CONCLUSIONS:
Because of this effect of modulating the cellular immune response, soya-cerebrosides I and II were considered to be the active substances of this ethno drug.
Zhongguo Zhong Yao Za Zhi. 2014 Jan;39(2):258-61.
[Chemical constituents from leaves of Ilex latifolia].[Pubmed:
24761642]
METHODS AND RESULTS:
Nine compounds were isolated from the leaves of Ilex latifolia. Their structures were respectively identified as 5-hydroxy-6, 7, 8, 4'-tetramethoxyflavone (1), tangeretin (2), nobiletin (3), 5-hydroxy-6, 7, 8, 3', 4'-pentamethoxyflavone (4), 5, 6, 7, 8, 4'-pentamethoxyflavonol (5), 5, 6, 7, 8, 3', 4'-hexamethoxy-flavonol (6), 5-hydroxy-3', 4', 7-trimethoxyflavanone (7), Soyacerebroside I (8), and Soyacerebroside II (9) by their physicochemical properties and spectroscopic data Compounds 1-9 were isolated from this plant for the first time.
