Polygalacin D

Polygalacin D
Product Name Polygalacin D
CAS No.: 66663-91-0
Catalog No.: CFN93351
Molecular Formula: C57H92O27
Molecular Weight: 1209.4 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: NOS | COX | PGE | NO | NF-kB
Source: The roots of Polygala tenuifolia Willd
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, and can suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Molecules.2019, 24(9):E1719
  • Toxicol Mech Methods.2021, 1-12.
  • Molecules.2020 ,25(16):3697.
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Molecules.2021, 26(18):5665.
  • PLoS One.2015, 10(5):e0127060
  • Nat Prod Commun.2017, 12(5):771-778
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Molecules.2020, 25(21):5091.
  • Journal of Apicultural Research2021, 60(1).
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