Deoxy euphorbia factor L1

Deoxy euphorbia factor L1
Product Name Deoxy euphorbia factor L1
CAS No.: 247099-01-0
Catalog No.: CFN95340
Molecular Formula: C32H40O7
Molecular Weight: 536.7 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Euphorbia pekinensis Rupr
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/10mg
Deoxy euphorbia factor L1 inhibits the growth of lung cancer A549 cells through the mitochondrial pathway (IC50 value of 17.51 ± 0.85 μM) and induces apoptosis.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Phytomedicine.2020, 153440.
  • Oxid Med Cell Longev2020, 12
  • Molecules.2021, 26(18):5665.
  • Current Pharmaceutical Analysis2017, 13(5)
  • Int J Biol Macromol.2021, 199:189-200.
  • Phytochemistry Letters2017, 449-455
  • Molecules.2018, 23(7):E1659
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • J Med Food.2020, 23(6):633-640.
  • Food Funct.2022, doi: 10.1039
  • Euphorbia factor L8

    Catalog No: CFN92886
    CAS No: 218916-53-1
    Price: $288/10mg
    Euphorbia factor L9

    Catalog No: CFN92887
    CAS No: 129393-28-8
    Price: $368/5mg
    Euphorbia factor L2

    Catalog No: CFN92884
    CAS No: 218916-51-9
    Price: $168/20mg
    17-Hydroxyisolathyrol

    Catalog No: CFN93011
    CAS No: 93551-00-9
    Price: Inquiry(manager@chemfaces.com)
    Euphorbia factor L22

    Catalog No: CFN95338
    CAS No: 1613700-09-6
    Price: $413/5mg
    Euphorbia factor L7a

    Catalog No: CFN92885
    CAS No: 93550-94-8
    Price: $298/10mg
    Euphorbia factor L7b

    Catalog No: CFN91052
    CAS No: 93550-95-9
    Price: $238/10mg
    Euphorbia factor L24

    Catalog No: CFN95334
    CAS No: 1613700-13-2
    Price: $318/5mg
    Jolkinol A

    Catalog No: CFN92878
    CAS No: 62820-11-5
    Price: Inquiry(manager@chemfaces.com)
    Epoxylathyrol

    Catalog No: CFN98559
    CAS No: 28649-60-7
    Price: Inquiry(manager@chemfaces.com)
    Molecules, 2017 Aug 25;22(9):1412.
    Structure Identification and In Vitro Anticancer Activity of Lathyrol-3-phenylacetate-5,15-diacetate[Pubmed: 28841191]
    Natural products from the genus Euphorbia show attention-attracting activities, such as anticancer activity. In this article, classical isolation and structure identification were used in a study on Caper Euphorbia Seed. Subsequently, MTT and wound healing assays, flow cytometry, western blotting, Hoechst 33258 staining and fluorescence microscopy examination were applied to investigate the anticancer activity of the obtained compounds. In a result, lathyrol-3-phenyl- acetate-5,15-diacetate (Deoxy euphorbia factor L1, DEFL1) was isolated from Caper Euphorbia Seed. Moreover, the NMR signals were totally assigned. DEFL1 showed potent inhibition against lung cancer A549 cells, with an IC50 value of 17.51 ± 0.85 μM. Furthermore, DEFL1 suppressed wound healing of A549 cells in a concentration-dependent manner. Mechanically, DEFL1 induced apoptosis, with involvement of an increase of reactive oxygen species (ROS), decrease of mitochondrial membrane potential (ΔΨm), release of cytochrome c, activity raise of caspase-9 and 3. Characteristic features of apoptosis were observed by fluorescence microscopy. In summary, DEFL1 inhibited growth and induced apoptosis in lung cancer A549 cells via a mitochondrial pathway.
    Caohuoside E

    Catalog No: CFN95016
    CAS No: 174286-23-8
    Price: $388/5mg
    Arjunglucoside I

    Catalog No: CFN95049
    CAS No: 62319-70-4
    Price: $268/10mg
    (1S,2S)-threo-Honokitriol

    Catalog No: CFN95076
    CAS No: 1099687-80-5
    Price: $413/5mg
    Mirificin-4'-O-glucoside

    Catalog No: CFN95091
    CAS No: 168035-01-6
    Price: $288/5mg
    Licoricesaponin H2

    Catalog No: CFN95173
    CAS No: 118441-85-3
    Price: $218/10mg
    Marginatoxin

    Catalog No: CFN95174
    CAS No: 1422536-56-8
    Price: $318/10mg
    Apigenin 6,8-di-C-alpha-L-arabinopyranoside

    Catalog No: CFN95360
    CAS No: 73140-47-3
    Price: $318/10mg
    Methylpicraquassioside B

    Catalog No: CFN95379
    CAS No: 1443757-89-8
    Price: $318/10mg
    2,11,12-Trihydroxy-7,20-epoxy-8,11,13-abietatriene

    Catalog No: CFN95428
    CAS No: 1608462-12-9
    Price: $318/10mg
    Epigambogellic acid

    Catalog No: CFN95438
    CAS No: 1352191-85-5
    Price: $318/5mg