Deoxy euphorbia factor L1

Deoxy euphorbia factor L1
Product Name Deoxy euphorbia factor L1
CAS No.: 247099-01-0
Catalog No.: CFN95340
Molecular Formula: C32H40O7
Molecular Weight: 536.7 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Euphorbia pekinensis Rupr
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/10mg
Deoxy euphorbia factor L1 inhibits the growth of lung cancer A549 cells through the mitochondrial pathway (IC50 value of 17.51 ± 0.85 μM) and induces apoptosis.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Molecules.2019, 25(1):E103
  • Biomed Pharmacother.2021, 137:111362.
  • Journal of Phytopathology2021, 169,Issue11-12.
  • J Ethnopharmacol.2023, 313:116534.
  • Drug Chem Toxicol.2020, 1-12.
  • Processes2020, 8(12),1540.
  • Front Nutr.2023, 10:1181135.
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Heinrich Heine University Dusseldorf2021, 62203.
  • Chinese Pharmaceutical Journal2023, 58(2):178-187.
  • Euphorbia factor L24

    Catalog No: CFN95334
    CAS No: 1613700-13-2
    Price: $318/5mg
    Jolkinol A

    Catalog No: CFN92878
    CAS No: 62820-11-5
    Price: Inquiry(manager@chemfaces.com)
    Epoxylathyrol

    Catalog No: CFN98559
    CAS No: 28649-60-7
    Price: Inquiry(manager@chemfaces.com)
    Euphorbia factor L25

    Catalog No: CFN95339
    CAS No: 303174-98-3
    Price: $368/5mg
    Euphorbia factor L1

    Catalog No: CFN92883
    CAS No: 76376-43-7
    Price: $80/20mg
    Deoxy euphorbia factor L1

    Catalog No: CFN95340
    CAS No: 247099-01-0
    Price: $318/10mg
    New compound 9

    Catalog No: CFN95342
    CAS No: N/A
    Price: $413/5mg
    7-beta-Hydroxylathyrol

    Catalog No: CFN92488
    CAS No: 34208-98-5
    Price: $148/20mg
    Euphorbia factor L3

    Catalog No: CFN99706
    CAS No: 218916-52-0
    Price: $80/20mg
    Euphorbia factor L8

    Catalog No: CFN92886
    CAS No: 218916-53-1
    Price: $288/10mg
    Molecules, 2017 Aug 25;22(9):1412.
    Structure Identification and In Vitro Anticancer Activity of Lathyrol-3-phenylacetate-5,15-diacetate[Pubmed: 28841191]
    Natural products from the genus Euphorbia show attention-attracting activities, such as anticancer activity. In this article, classical isolation and structure identification were used in a study on Caper Euphorbia Seed. Subsequently, MTT and wound healing assays, flow cytometry, western blotting, Hoechst 33258 staining and fluorescence microscopy examination were applied to investigate the anticancer activity of the obtained compounds. In a result, lathyrol-3-phenyl- acetate-5,15-diacetate (Deoxy euphorbia factor L1, DEFL1) was isolated from Caper Euphorbia Seed. Moreover, the NMR signals were totally assigned. DEFL1 showed potent inhibition against lung cancer A549 cells, with an IC50 value of 17.51 ± 0.85 μM. Furthermore, DEFL1 suppressed wound healing of A549 cells in a concentration-dependent manner. Mechanically, DEFL1 induced apoptosis, with involvement of an increase of reactive oxygen species (ROS), decrease of mitochondrial membrane potential (ΔΨm), release of cytochrome c, activity raise of caspase-9 and 3. Characteristic features of apoptosis were observed by fluorescence microscopy. In summary, DEFL1 inhibited growth and induced apoptosis in lung cancer A549 cells via a mitochondrial pathway.
    Epimedin K

    Catalog No: CFN95019
    CAS No: 174286-13-6
    Price: $288/5mg
    Isoeuphorbetin

    Catalog No: CFN95207
    CAS No: 50677-55-9
    Price: $318/5mg
    Stevia impurity (13-[(2-O-6-deoxy-beta-D-glucopyranosyl-3-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid beta-D-glucopyranosyl ester)

    Catalog No: CFN95229
    CAS No: 1309929-72-3
    Price: $463/5mg
    Arganine B

    Catalog No: CFN95281
    CAS No: 144425-21-8
    Price: $318/5mg
    Isophysalin G

    Catalog No: CFN95328
    CAS No: 152221-21-1
    Price: $368/5mg
    Toddalolactone 3'-O-methyl ether (6-(2-Hydroxy-3-methoxy-3-methylbutyl)-5,7-dimethoxycoumarin)

    Catalog No: CFN95372
    CAS No: 143614-35-1
    Price: $318/10mg
    Orthosiphol A

    Catalog No: CFN95442
    CAS No: 142741-25-1
    Price: $318/5mg
    Massonianoside D

    Catalog No: CFN95500
    CAS No: 85115-04-4
    Price: $318/10mg
    Symplocoside

    Catalog No: CFN95552
    CAS No: 76502-76-6
    Price: $318/5mg
    Mahuannin B

    Catalog No: CFN95554
    CAS No: 82796-37-0
    Price: $318/5mg