Platycodin D2

Platycodin D2
Product Name Platycodin D2
CAS No.: 66663-90-9
Catalog No.: CFN93260
Molecular Formula: C63H102O33
Molecular Weight: 1387.5 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: IFN-γ | IL Receptor | HBV
Source: The roots of Platycodon grandiflorum.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalacin D2 has anti-cancer activity, it exhibits significant inhibition on the proliferation of five kinds of cultured human tumor cell lines.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Natural Product Communications2022, 7(3):1-7.
  • Front Pharmacol.2021, 12:635510.
  • J Ethnopharmacol.2020, 249:112381
  • PLoS One.2017, 12(3):e0173585
  • Phytomedicine.2019, 59:152785
  • Aquaculture2019, 510:392-399
  • Integr Med Res.2021, 10(3):100723.
  • Drug Invention Today2019, 12(6):1303-1306
  • Onco Targets Ther.2017, 10:3467-3474
  • Drug Test Anal.2018, 10(10):1579-1589
  • Platycodin D2

    Catalog No: CFN93260
    CAS No: 66663-90-9
    Price: Inquiry(manager@chemfaces.com)
    Platycoside E

    Catalog No: CFN90786
    CAS No: N/A
    Price: Inquiry(manager@chemfaces.com)
    Celosin H

    Catalog No: CFN91669
    CAS No: 1623405-28-6
    Price: $268/10mg
    Celosin I

    Catalog No: CFN91061
    CAS No: 1807732-38-2
    Price: $238/5mg
    Celosin J

    Catalog No: CFN91152
    CAS No: 1623405-29-7
    Price: $388/5mg
    Polygalasaponin XXXV

    Catalog No: CFN95176
    CAS No: 184479-28-5
    Price: $463/5mg
    Onjisaponin B

    Catalog No: CFN90600
    CAS No: 35906-36-6
    Price: $298/10mg
    Polygalasaponin XXXI

    Catalog No: CFN90728
    CAS No: 79103-90-5
    Price: $268/5mg
    Polygalasaponin XLIX

    Catalog No: CFN95117
    CAS No: 1033593-12-2
    Price: $318/10mg
    Ilexoside XLVIII

    Catalog No: CFN91698
    CAS No: 129095-76-7
    Price: $318/5mg
    Planta Med. 2005 Jun;71(6):566-8.
    Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines.[Pubmed: 15971131]

    METHODS AND RESULTS:
    A novel triterpenoid saponin, deapioplatycoside E (1) was isolated from the root extract of Platycodon grandiflorum, together with the seven known saponins 2 - 8, i. e., platycoside E (2), deapioplatycodin D3 (3), platycodin D3 (4), polygalacin D2 (5), Platycodin D2 (6), deapioplatycodin D (7) and platycodin D (8). The structure of the new saponin 1 was determined on the basis of spectral analysis and chemical evidence.
    CONCLUSIONS:
    The crude saponin fraction (ED50: ca. 10 - 15 microg/mL) and compounds 6 - 8 (ED50: ca. 4 - 18 microg/mL) exhibited significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.
    Chem Biodivers. 2010 Jan;7(1):178-85.
    Platycodin D2 improves specific cellular and humoral responses to hepatitis B surface antigen in mice.[Pubmed: 20087984 ]
    Platycodin D2 (PD2), a saponin isolated from the root of Platycodon grandiflorum, was evaluated for its haemolytic activity and adjuvant potential on the cellular and humoral immune responses to ovalbumin (OVA) in ICR mice.
    METHODS AND RESULTS:
    The HD(50) values of PD2 and Quil A were 18.57+/-1.37 and 5.76+/-0.23 microg/ml against 0.5% rabbit red blood cell, respectively, implicating the less haemolytic activity for PD2 than Quil A. ICR mice were immunized subcutaneously with OVA 100 microg alone or with OVA 100 microg dissolved in saline containing Alum (200 microg), or PD2 (25, 50, 75 or 100 microg) on Day 1 and 15. Two weeks later (Day 28), concanavalin A (Con A)-, lipopolysaccharide (LPS-) and OVA-stimulated splenocyte proliferation and OVA-specific antibodies in serum were measured. PD2 significantly enhanced the Con A-, LPS-, and OVA-induced splenocyte proliferation in the OVA-immunized mice (P<0.05, P<0.01 or P<0.001). OVA-specific IgG, IgG1, IgG2a, and IgG2b antibody titers in serum were also significantly enhanced by PD2 compared with OVA control group (P<0.05, P<0.01 or P<0.001). Further, the effects of PD2 on mRNA expression of cytokines and transcription factors in Con A-stimulated mice splenocytes were evaluated by RT-PCR analysis. PD2 significantly promoted the mRNA expression of cytokines IL-2, IFN-gamma, IL-4, and IL-10 and transcription factors T-bet and GATA-3 (P<0.05, P<0.01 or P<0.001).
    CONCLUSIONS:
    In conclusion, the results suggest that PD2 could be safely used as adjuvant eliciting Th1 and Th2 immune responses.
    Int Immunopharmacol. 2008 Aug;8(8):1143-50.
    Platycodin D2 is a potential less hemolytic saponin adjuvant eliciting Th1 and Th2 immune responses.[Pubmed: 18550019 ]
    Platycodin D2 (PD2), a saponin isolated from the root of Platycodon grandiflorum, was evaluated for its haemolytic activity and adjuvant potential on the cellular and humoral immune responses to ovalbumin (OVA) in ICR mice.
    METHODS AND RESULTS:
    The HD(50) values of PD2 and Quil A were 18.57+/-1.37 and 5.76+/-0.23 microg/ml against 0.5% rabbit red blood cell, respectively, implicating the less haemolytic activity for PD2 than Quil A. ICR mice were immunized subcutaneously with OVA 100 microg alone or with OVA 100 microg dissolved in saline containing Alum (200 microg), or PD2 (25, 50, 75 or 100 microg) on Day 1 and 15. Two weeks later (Day 28), concanavalin A (Con A)-, lipopolysaccharide (LPS-) and OVA-stimulated splenocyte proliferation and OVA-specific antibodies in serum were measured. PD2 significantly enhanced the Con A-, LPS-, and OVA-induced splenocyte proliferation in the OVA-immunized mice (P<0.05, P<0.01 or P<0.001). OVA-specific IgG, IgG1, IgG2a, and IgG2b antibody titers in serum were also significantly enhanced by PD2 compared with OVA control group (P<0.05, P<0.01 or P<0.001). Further, the effects of PD2 on mRNA expression of cytokines and transcription factors in Con A-stimulated mice splenocytes were evaluated by RT-PCR analysis. PD2 significantly promoted the mRNA expression of cytokines IL-2, IFN-gamma, IL-4, and IL-10 and transcription factors T-bet and GATA-3 (P<0.05, P<0.01 or P<0.001).
    CONCLUSIONS:
    In conclusion, the results suggest that PD2 could be safely used as adjuvant eliciting Th1 and Th2 immune responses.
    Isoformononetin

    Catalog No: CFN95024
    CAS No: 486-63-5
    Price: $288/5mg
    3''-Galloylquercitrin

    Catalog No: CFN95048
    CAS No: 503446-90-0
    Price: $368/5mg
    Lonicerin

    Catalog No: CFN95055
    CAS No: 25694-72-8
    Price: $168/10mg
    Andrographidine A

    Catalog No: CFN95210
    CAS No: 113963-37-4
    Price: $318/5mg
    Lyciumamide B

    Catalog No: CFN95286
    CAS No: 1647111-41-8
    Price: $318/5mg
    Deoxy euphorbia factor L1

    Catalog No: CFN95340
    CAS No: 247099-01-0
    Price: $318/10mg
    Toddalolactone 3'-O-methyl ether (6-(2-Hydroxy-3-methoxy-3-methylbutyl)-5,7-dimethoxycoumarin)

    Catalog No: CFN95372
    CAS No: 143614-35-1
    Price: $318/10mg
    5,6,7,3',4'-Pentamethoxyflavanone

    Catalog No: CFN95394
    CAS No: 104193-93-3
    Price: $318/5mg
    Tumulosic acid

    Catalog No: CFN95399
    CAS No: 508-24-7
    Price: $413/5mg
    Murracarpin

    Catalog No: CFN95409
    CAS No: 120786-76-7
    Price: $413/5mg