Marginatoxin

Marginatoxin
Product Name Marginatoxin
CAS No.: 1422536-56-8
Catalog No.: CFN95174
Molecular Formula: C22H22O7
Molecular Weight: 398.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Targets: Caspase | Fas/FasL
Source: The roots of Bupleurum marginatum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/10mg
Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Phytochemistry Letters2017, 449-455
  • Molecules.2022, 27(13):4227.
  • Biomed Pharmacother.2020, 128:110318.
  • Advances in Traditional Medicine2020, 10.1007
  • PLoS One.2022, 17(6):e0268505.
  • Talanta.2023, 262:124690.
  • JEJU National University2022, 10478.
  • Int J Mol Sci.2022, 23(23):15213.
  • Br J Pharmacol.2018, 175(6):902-923
  • Int J Mol Sci.2022, 23(21):13406.
  • gamma-Diasarone

    Catalog No: CFN97279
    CAS No: 80434-33-9
    Price: Inquiry(manager@chemfaces.com)
    alpha-Conidendrin

    Catalog No: CFN97420
    CAS No: 85699-62-3
    Price: Inquiry(manager@chemfaces.com)
    Isoanthricin

    Catalog No: CFN92623
    CAS No: 17301-70-5
    Price: Inquiry(manager@chemfaces.com)
    alpha-Peltatin

    Catalog No: CFN70412
    CAS No: 568-53-6
    Price: Inquiry(manager@chemfaces.com)
    (-)-beta-Peltatin

    Catalog No: CFN92699
    CAS No: 518-29-6
    Price: Inquiry(manager@chemfaces.com)
    (-)-beta-Peltatin-5-O-beta-D-glucopyranoside

    Catalog No: CFN92700
    CAS No: 11024-59-2
    Price: Inquiry(manager@chemfaces.com)
    Deoxypodophyllotoxin

    Catalog No: CFN99888
    CAS No: 19186-35-7
    Price: $268/10mg
    4'-Demethylpodophyllotoxin

    Catalog No: CFN90483
    CAS No: 40505-27-9
    Price: $40/20mg
    Etoposide

    Catalog No: CFN89061
    CAS No: 33419-42-0
    Price: $50/20mg
    Podophyllotoxinone

    Catalog No: CFN91909
    CAS No: 477-49-6
    Price: Inquiry(manager@chemfaces.com)
    Phytochemistry Letters, 2012, 5(2):387-392.
    A novel cytotoxic aryltetraline lactone from Bupleurum marginatum (Apiaceae)[Reference: WebLink]

    METHODS AND RESULTS:
    A detailed phytochemical study of the aerial parts of Bupleurum marginatum Wall. ex DC revealed a novel aryltetraline lactone lignan identified as 9-(benzo[d][1,3]dioxol-5-yl)-6,7,8-trimethoxy-3a,4,9,9a-tetrahydronaphtho[2,3-c]furan-1(3H)-one (Marginatoxin) along with nine known compounds and characterization of five other compounds either by GLC/MS or LC/MS techniques. Chemical structures of the isolated compounds were unambiguously elucidated by both 1D, 2D NMR and mass spectrometry techniques.The in vitro cytotoxic activity of both methanol and dichloromethane extracts as well as the isolated compounds was assessed in two human cancer cell lines HepG2 and HeLa using the MTT assay.
    CONCLUSIONS:
    The new aryltetraline lactone lignan exhibited a potent cytotoxic activity with IC50 values of 12.14 and 16.90 μM after 24 h treatment for HepG2 and HeLa cells, respectively.
    Biomedical Research,2017,28(3).
    Marginatoxin induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.[Reference: WebLink]
    Marginatoxin, an aryltetraline lactone lignan isolated from Bupleurum marginatum Wall. ex DC (Apiaceae), showed cytotoxic activity against human hepatocellular carcinoma. However, the cytotoxic mechanisms of Marginatoxin against cancer cells remained unclear.
    METHODS AND RESULTS:
    This study was designed to investigate the detailed mechanism of its cytotoxic effect on human hepatoma BEL-7402 cells by CCK-8, flow cytometry, western blot and xenograft assays. Marginatoxin caused a dose-dependent growth inhibition of BEL-7402 cells with an IC50 of 15.20 μg/ml. Marginatoxin induced BEL-7402 cells apoptosis identified by annexing V/propidium iodide staining kits with the aid of flow cytometry. Marginatoxin-induced apoptosis was characterized by increasing Fas, FasL and Fas associated protein with death domain expression, and cleavage of caspase-8, caspase-10, caspase-3. Furthermore, the results of xenograft assay suggested that Marginatoxin inhibited the BEL-7402 cells-induced tumor growth without effect on body weight of nude mice in vivo by regulating the expression levels of above apoptotic proteins. These results demonstrated that Marginatoxin could induce apoptosis of human hepatoma BEL-7402 cells in vitro and in vivo through activation of Fas/FasL-mediated apoptotic pathway.
    CONCLUSIONS:
    All these findings demonstrated that Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma. Moreover, there is a need to further investigate Marginatoxin in this regard.
    Columbianetin beta-D-glucopyranoside

    Catalog No: CFN95038
    CAS No: 55836-35-6
    Price: $288/5mg
    5,7,2',4'-Tetrahydroxy-8,3'-di(gamma,gamma-dimethylallyl)-isoflavanone

    Catalog No: CFN95084
    CAS No: 141846-47-1
    Price: $413/5mg
    Momordicine V

    Catalog No: CFN95164
    CAS No: 1012315-36-4
    Price: $463/5mg
    Lyciumamide B

    Catalog No: CFN95286
    CAS No: 1647111-41-8
    Price: $318/5mg
    Barbaloin-related compound B

    Catalog No: CFN95455
    CAS No: 473225-22-8
    Price: $318/5mg
    8-Epiloganin

    Catalog No: CFN95478
    CAS No: 79172-04-6
    Price: $318/20mg
    3-Oxo-alpha-ilexanolic acid

    Catalog No: CFN95496
    CAS No: N/A
    Price: $413/5mg
    10-Deacetylcephalomannine

    Catalog No: CFN95519
    CAS No: 76429-85-1
    Price: $318/10mg
    Methyl ganoderate B

    Catalog No: CFN95551
    CAS No: 81907-65-5
    Price: $413/5mg
    Calleryanin

    Catalog No: CFN95556
    CAS No: 20300-53-2
    Price: $318/5mg