Luteolin 7,3'-di-O-glucuronide

Phytomedicine (Jena), 2007, 14(6):409-415.

Antispasmodic activity of an extract from Plantago lanceolata L. and some isolated compounds.[Reference: WebLink]

METHODS AND RESULTS:
An ethanolic spissum extract of the aerial parts of Plantago lanceolata L. was examined for antispasmodic activity on isolated ileum and trachea of the guinea-pig. Isolated constituents were investigated as well. The P. lanceolata extract inhibited the contractions of the guinea-pig ileum that were induced by various agonists such as acetylcholine (ACh), histamine, potassium and barium ions. Additionally the trachea contractions induced by barium ions were inhibited. The compounds luteolin, acteoside, plantamajoside an catalpol peracetate but not catalpol, isoacteoside, lavandulifolioside and aucubin inhibited the ACh-induced contractions of the guinea-pig ileum. Luteolin and acteoside reduced the barium-induced contractions of the guinea-pig trachea.
CONCLUSIONS:
Two recently isolated compounds did not show antispasmodic activity: luteolin-3',7-diglucuronide(Luteolin 7,3'-di-O-glucuronide ) and beta-hydroxy-acteoside.

Phytochemistry,1974,13(9):1937-1942.

Flavonoids of the liverwort Marchantia polymorpha.[Reference: WebLink]

METHODS AND RESULTS:
The major flavonoids of Marchantia polymorpha var. polymorpha and aquatica are the 7-O-β-d-glucuronides of apigenin and luteolin, luteolin 3′-O-β-d-glucuronide, luteolin 7,3′-di-O-β-d-glucuronide(Luteolin 7,3'-di-O-glucuronide ), and the 7,4′-di-O-β-d-glucuronides of apigenin and luteolin.
CONCLUSIONS:
These are accompanied by minor amounts of apigenin, luteolin, luteolin 3′,4′-di-O-β-d-glucuronide and luteolin 7,3′,4′-tri-O-β-d-glucuronide. All the luteolin di- and triglucuronides except the 3′,4′-di- substituted compound are new natural products.