Licoricone

Licoricone
Product Name Licoricone
CAS No.: 51847-92-8
Catalog No.: CFN96504
Molecular Formula: C22H22O6
Molecular Weight: 382.41 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: Antifection
Source: The roots of Glycyrrhiza uralensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $333/5mg
Licoricone exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Pharm Biomed Anal.2019, 172:268-277
  • J Asian Nat Prod Res.2019, 5:1-17
  • J of Health Science and Alternative Medicine2019, 1(1)
  • J Nat Prod.2019, 82(4):1002-1008
  • Phytochemistry.2017, 141:162-170
  • J Ethnopharmacol.2017, 198:91-97
  • Acta Chromatographica2016, 29(3)
  • Mol Cell.2017, 68(4):673-685
  • BMC Complement Altern Med.2019, 19(1):11
  • J Ethnopharmacol.2019, 236:31-41
  • Isoneobavaisoflavone

    Catalog No: CFN92223
    CAS No: 40357-43-5
    Price: Inquiry(manager@chemfaces.com)
    Glabrone

    Catalog No: CFN93041
    CAS No: 60008-02-8
    Price: Inquiry(manager@chemfaces.com)
    Neobavaisoflavone

    Catalog No: CFN92222
    CAS No: 41060-15-5
    Price: $128/20mg
    Isowighteone

    Catalog No: CFN97166
    CAS No: 68436-47-5
    Price: $398/5mg
    Isoderrone

    Catalog No: CFN92794
    CAS No: 121747-89-5
    Price: Inquiry(manager@chemfaces.com)
    Eurycarpin A

    Catalog No: CFN97806
    CAS No: 166547-20-2
    Price: Inquiry(manager@chemfaces.com)
    Licoisoflavone A

    Catalog No: CFN90816
    CAS No: 66056-19-7
    Price: $270/5mg
    Licoisoflavone B

    Catalog No: CFN96405
    CAS No: 66056-30-2
    Price: $368/5mg
    Glycyrrhisoflavone

    Catalog No: CFN90817
    CAS No: 116709-70-7
    Price: $368/10mg
    Semilicoisoflavone B

    Catalog No: CFN90818
    CAS No: 129280-33-7
    Price: $318/5mg
    Life Sci. 2002 Aug 9;71(12):1449-63.
    Anti-Helicobacter pylori flavonoids from licorice extract.[Pubmed: 12127165]
    Licorice is the most used crude drug in Kampo medicines (traditional Chinese medicines modified in Japan). The extract of the medicinal plant is also used as the basis of anti-ulcer medicines for treatment of peptic ulcer.
    METHODS AND RESULTS:
    Among the chemical constituents of the plant, glabridin and glabrene (components of Glycyrrhiza glabra), licochalcone A (G. inflata), licoricidin and licoisoflavone B (G. uralensis) exhibited inhibitory activity against the growth of Helicobacter pylori in vitro. These flavonoids also showed anti-H. pylori activity against a clarithromycin (CLAR) and amoxicillin (AMOX)-resistant strain. We also investigated the methanol extract of G. uralensis. From the extract, three new isoflavonoids (3-arylcoumarin, pterocarpan, and isoflavan) with a pyran ring, gancaonols A[bond]C, were isolated together with 15 known flavonoids. Among these compounds, vestitol, Licoricone, 1-methoxyphaseollidin and gancaonol C exhibited anti-H. pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. Glycyrin, formononetin, isolicoflavonol, glyasperin D, 6,8-diprenylorobol, gancaonin I, dihydrolicoisoflavone A, and gancaonol B possessed weaker anti-H. pylori activity.
    CONCLUSIONS:
    These compounds may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals.
    Future Microbiol. 2015;10(12):1953-68.
    Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids.[Pubmed: 26582430 ]
    To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii.
    METHODS AND RESULTS:
    Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm formation and production of antioxidant enzymes. Mechanistically, F1 downregulated the expression of autoinducer synthase gene, abaI, and consequently reduced (92%) the production of 3-OH-C12-HSL as determined by ESI-MS. Q-TOF and Q-TRAP analyses suggested the presence of flavonoids viz. Licoricone, glycyrin and glyzarin as the active ingredients.
    CONCLUSIONS:
    This is the first report on quorum quenching activity of G. glabra linked to its flavonoids that downregulated the expression of abaI and attenuated quorum sensing regulated virulence of A. baumannii.
    Glycitein

    Catalog No: CFN99106
    CAS No: 40957-83-3
    Price: $128/20mg
    4'-O-Methylbroussochalcone B

    Catalog No: CFN98046
    CAS No: 20784-60-5
    Price: $198/20mg
    Oroxylin A 7-O-beta-D-glucuronide

    Catalog No: CFN90191
    CAS No: 36948-76-2
    Price: $318/20mg
    Gypenoside XVII

    Catalog No: CFN90193
    CAS No: 80321-69-3
    Price: $148/20mg
    Didymin

    Catalog No: CFN92363
    CAS No: 14259-47-3
    Price: $128/20mg
    meso-Hannokinol

    Catalog No: CFN90864
    CAS No: N/A
    Price: $368/5mg
    Isololiolide

    Catalog No: CFN95106
    CAS No: 38274-00-9
    Price: $388/5mg
    Momordicine II

    Catalog No: CFN95167
    CAS No: 91590-75-9
    Price: $318/10mg
    6'-Feruloylnodakenin

    Catalog No: CFN95202
    CAS No: 131623-14-8
    Price: $318/10mg
    Isoeuphorbetin

    Catalog No: CFN95207
    CAS No: 50677-55-9
    Price: $318/5mg