Semilicoisoflavone B

Semilicoisoflavone B
Product Name Semilicoisoflavone B
CAS No.: 129280-33-7
Catalog No.: CFN90818
Molecular Formula: C20H16O6
Molecular Weight: 352.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Glycyrrhiza uralensis Fisch
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/5mg
Semilicoisoflavone B can inhibit sorbitol formation of rat lens incubated with a high concentration of glucose, indicates that it may be effective for preventing osmotic stress in hyperglycemia.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Integr Cancer Ther.2018, 17(3):832-843
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Biomol Ther (Seoul).2019, 10.4062
  • Process Biochemistry2019, 87:213-220
  • Environ Toxicol.2019, 34(12):1354-1362
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Int J Mol Sci.2018, 19(9):E2528
  • Curr Eye Res.2018, 43(1):27-34
  • Antioxidants (Basel).2020, 9(2):E99
  • Licoisoflavone A

    Catalog No: CFN90816
    CAS No: 66056-19-7
    Price: $270/5mg
    Licoisoflavone B

    Catalog No: CFN96405
    CAS No: 66056-30-2
    Price: $368/5mg
    Glycyrrhisoflavone

    Catalog No: CFN90817
    CAS No: 116709-70-7
    Price: $368/10mg
    Semilicoisoflavone B

    Catalog No: CFN90818
    CAS No: 129280-33-7
    Price: $318/5mg
    Glicoricone

    Catalog No: CFN95063
    CAS No: 161099-37-2
    Price: $333/5mg
    Licoricone

    Catalog No: CFN96504
    CAS No: 51847-92-8
    Price: $333/5mg
    Isoneobavaisoflavone

    Catalog No: CFN92223
    CAS No: 40357-43-5
    Price: Inquiry(manager@chemfaces.com)
    Glabrone

    Catalog No: CFN93041
    CAS No: 60008-02-8
    Price: Inquiry(manager@chemfaces.com)
    Neobavaisoflavone

    Catalog No: CFN92222
    CAS No: 41060-15-5
    Price: $128/20mg
    Isowighteone

    Catalog No: CFN97166
    CAS No: 68436-47-5
    Price: $398/5mg
    Biol. Pharm. Bull., 2010, 33(5):917-21.
    Aldose reductase inhibitory compounds from Glycyrrhiza uralensis.[Pubmed: 20460778]

    METHODS AND RESULTS:
    We evaluated the inhibitory effects of components from the root of Glycyrrhiza uralensis (G. uralensis) on aldose reductase (AR) and sorbitol formation in rat lenses with high levels of glucose as part of our ongoing search of natural sources for therapeutic and preventive agents for diabetic complications. In order to identify the bioactive components of G. uralensis, 5 prenylated flavonoids (Semilicoisoflavone B, 7-O-methylluteone, dehydroglyasperin C, dehydroglyasperin D, and isoangustone A), three flavonoids (liquiritigenin, isoliquiritigenin, and licochalcone A), and two triterpenoids (glycyrrhizin and glycyrrhetinic acid) were isolated; their chemical structures were then elucidated on the basis of spectroscopic evidence and comparison with published data. The anti-diabetic complication activities of 10 G. uralensis-derived components were investigated via inhibitory assays using rat lens AR (rAR) and human recombinant AR (rhAR). From the 10 isolated compounds, Semilicoisoflavone B showed the most potent inhibition, with the IC(50) values of rAR and rhAR at 1.8 and 10.6microM, respectively.
    CONCLUSIONS:
    In the kinetic analyses using Lineweaver.Burk plots of 1/velocity and 1/concentration of substrate, Semilicoisoflavone B showed noncompetitive inhibition against rhAR. The results clearly indicated that the presence of a gamma,gamma-dimethylchromene ring is partly responsible for the AR inhibitory activity of isoprenoid-type flavonoids. Further, Semilicoisoflavone B inhibited sorbitol formation of rat lens incubated with a high concentration of glucose, indicating that this compound may be effective for preventing osmotic stress in hyperglycemia.
    Isochlorogenic acid C

    Catalog No: CFN99120
    CAS No: 32451-88-0
    Price: $100/20mg
    Brevilin A

    Catalog No: CFN99694
    CAS No: 16503-32-5
    Price: $218/10mg
    11-Hydroxycanthin-6-one

    Catalog No: CFN92125
    CAS No: 75969-83-4
    Price: $413/5mg
    Batatasin III

    Catalog No: CFN92689
    CAS No: 56684-87-8
    Price: $368/5mg
    Glucoliquiritin

    Catalog No: CFN95011
    CAS No: 93446-18-5
    Price: $318/10mg
    Kobusin

    Catalog No: CFN89280
    CAS No: 36150-23-9
    Price: $318/10mg
    Selaginellin F

    Catalog No: CFN95029
    CAS No: 1340493-24-4
    Price: $413/5mg
    Carasinol B

    Catalog No: CFN95042
    CAS No: 777857-86-0
    Price: $333/5mg
    Kakkalide

    Catalog No: CFN95052
    CAS No: 58274-56-9
    Price: $260/10mg
    Dihydrowithaferin A

    Catalog No: CFN91055
    CAS No: 5589-41-3
    Price: $258/5mg