Licoisoflavone A

Licoisoflavone A
Product Name Licoisoflavone A
CAS No.: 66056-19-7
Catalog No.: CFN90816
Molecular Formula: C20H18O6
Molecular Weight: 354.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: MRP
Source: The roots of Glycyrrhiza uralensis Fisch
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $270/5mg
Licoisoflavone A is a potential MRP inhibitor, it shows inhibitory effects on copper-induced protein oxidative modification of mice brain homogenate in vitro.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Academic J of Second Military Medical University2018, 39(11)
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Front Pharmacol.2018, 9:756
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • J-STAGE2015, 249-255
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • New Zealand J. Forestry Sci.2014, 44:17
  • Phytomedicine.2019, 61:152813
  • Mol Med Rep.2015, 12(5):7789-95
  • Genes Genomics.2020, 10.1007
  • Semilicoisoflavone B

    Catalog No: CFN90818
    CAS No: 129280-33-7
    Price: $318/5mg
    Glicoricone

    Catalog No: CFN95063
    CAS No: 161099-37-2
    Price: $333/5mg
    Licoricone

    Catalog No: CFN96504
    CAS No: 51847-92-8
    Price: $333/5mg
    Isoneobavaisoflavone

    Catalog No: CFN92223
    CAS No: 40357-43-5
    Price: Inquiry(manager@chemfaces.com)
    Glabrone

    Catalog No: CFN93041
    CAS No: 60008-02-8
    Price: Inquiry(manager@chemfaces.com)
    Neobavaisoflavone

    Catalog No: CFN92222
    CAS No: 41060-15-5
    Price: $128/20mg
    Isowighteone

    Catalog No: CFN97166
    CAS No: 68436-47-5
    Price: $398/5mg
    Isoderrone

    Catalog No: CFN92794
    CAS No: 121747-89-5
    Price: Inquiry(manager@chemfaces.com)
    Eurycarpin A

    Catalog No: CFN97806
    CAS No: 166547-20-2
    Price: Inquiry(manager@chemfaces.com)
    Licoisoflavone A

    Catalog No: CFN90816
    CAS No: 66056-19-7
    Price: $270/5mg
    Biol Trace Elem Res. 2001 Aug;81(2):169-75.
    Inhibitory effects of licoisoflavones A and B and sophoraisoflavone A of Sophra mooracroftiana Beth ex Baker on copper-ion-induced protein oxidative modification of mice brain homogenate, in vitro.[Pubmed: 11554397]

    METHODS AND RESULTS:
    We present the results of an in vitro investigation of the inhibitory effects of licoisoflavones A and B and sophoraisoflavone A isolated from Sophra mooracroftiana BETH ex BAKER on copper-induced protein oxidative modification of mice brain homogenate in vitro. Although inhibitory effect of sophoraisoflavone A was stronger than those of licoisoflavones A and B, genistein as a related isoflavone, and mannitol as a hydroxy radical scavenger, inhibitory effects of licoisoflavones A and B were weaker than those of genistein and mannitol.
    CONCLUSIONS:
    These results demonstrated that the difference of inhibitory effects are dependent on the relation between chemical structures of these isoflavones, such as hydroxy group or benzopyran, and oxidative stress.
    Blood Cells Mol Dis. 2001 Sep-Oct;27(5):894-900.
    Monitoring of MRP-like activity in human erythrocytes: inhibitory effect of isoflavones.[Pubmed: 11783953]
    A method to fluorometrically monitor efflux of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from human erythrocytes was developed. Genistein, daidzein, sophoraisoflavone A, and Licoisoflavone A induced 50% inhibition (IC(50)) of BCPCF efflux at 15-70 microM. The IC(50) value of the most efficient isoflavone, Licoisoflavone A (15-25 microM), was comparable to that of indomethacin (approximately 10 microM) and markedly lower than for probenecid (100-200 microM), both known MRP1 inhibitors.
    CONCLUSIONS:
    Our results indicate that the human erythrocyte is a useful cell model in screening potential MRP inhibitors, that BCPCF is a good substrate for MRP, and that some isoflavones at low concentrations inhibit MRP-mediated efflux.
    Hastatoside

    Catalog No: CFN96588
    CAS No: 50816-24-5
    Price: $268/20mg
    Viscumneoside III

    Catalog No: CFN89421
    CAS No: 118985-27-6
    Price: $288/10mg
    Angelol G

    Catalog No: CFN92988
    CAS No: 83199-38-6
    Price: $198/10mg
    Clemastanin B

    Catalog No: CFN95064
    CAS No: 112747-98-5
    Price: $298/10mg
    Asiaticoside B

    Catalog No: CFN95124
    CAS No: 125265-68-1
    Price: $198/20mg
    Puerol B

    Catalog No: CFN95155
    CAS No: 112343-17-6
    Price: $398/5mg
    Momordicine II

    Catalog No: CFN95167
    CAS No: 91590-75-9
    Price: $318/10mg
    Yuanhunine

    Catalog No: CFN95179
    CAS No: 104387-15-7
    Price: $368/5mg
    Astin C

    Catalog No: CFN95189
    CAS No: 148057-23-2
    Price: $318/10mg
    Arisanschinin E

    Catalog No: CFN95221
    CAS No: 1333378-33-8
    Price: Inquiry(manager@chemfaces.com)