Koenigicine
Koenigicine has pancreatic lipase (PL) inhibitory activity in vitro.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Plant Cell, Tissue and Organ Culture (PCTOC)2024, 158:54
FASEB J.2022, 36(7):e22387.
ACS Synth Biol.2022, doi: 10.1021.
Viruses.2024, 16(7):1128.
Pathogens.2018, 7(3):E62
Molecules.2018, 23(11):E2837
FEBS J.2022, 10.1111:febs.16676.
Horticulture Research2023, uhad164.
Nutr Res Pract.2023, 17(4):670-681.
Phytochemistry.2017, 141:162-170
Related and Featured Products
Natural Product Communications, 2009, 4(8):1089-1092.
Pancreatic lipase inhibitory alkaloids of Murraya koenigii leaves.[Reference:
WebLink]
In the continuing search for newer pancreatic lipase inhibitors from plants, a total of 63 extracts from 21 different plants were screened to study their pancreatic lipase (PL) inhibitory activity in vitro.
METHODS AND RESULTS:
All three extracts (DCM, EtOAc and MeOH) of Murraya koenigii (L.) Spreng leaves (Rutaceae) exhibited antilipase activity greater than 80%. Further, bioactivity guided fractionation of the EtOAc extract led to the isolation of four alkaloids, namely mahanimbin, koenimbin, Koenigicine and clausazoline-K, with IC50 values of 17.9 microM, 168.6 microM, 428.6 microM and <500 microM, respectively.
CONCLUSIONS:
This study reports for the first time the PL inhibitory potential of carbazole alkaloids from plants.
