Demethylmurrayanine
O-Demethylmurrayanine and clausine D exhibit strong cytotoxicity against MCF-7 and SMMC-7721 with IC50 values in the range 2.63-7.59 ug/ml.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Appl. Sci.2023, 13(17):9984.
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Mol Plant Pathol.2022, 10.1111:mpp.13280.
Neuroscience.2024, 559:77-90.
Separations2023, 10(11), 567;
The Pharmaceutical Society of Japan2018, 138(4):571-579
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Phytochem. Lett.,2014, 9(3):92-95.
Two new cytotoxic constituents from the Clausena lansium (Lour.) Skeels[Reference:
WebLink]
METHODS AND RESULTS:
Two new compounds 6-methoxy-9H-carbazole-3-carboxylic acid ( 1 ) and 9-[3-methyl-4-(4-methyl-5-oxo-tetrapydro-furan-2-yl)-but-2-enyloxy]-furo[3,2-g]chromen-7-one ( 5 ) along with four known compounds clausine D ( 2 ), claulansines J ( 3 ), O-Demethylmurrayanine ( 4 ) and pabularinone ( 6 ) were isolated from the Clausena lansium . The chemical structures of the new compound were elucidated by 1D and 2D NMR as well as HR-ESIMS spectral analysis. All the compounds isolated were evaluated for cytotoxic effects against human breast cancer (MCF-7), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721).
CONCLUSIONS:
Compounds 2 and 4 exhibited strong cytotoxicity against MCF-7 and SMMC-7721 with IC 50 values in the range 2.63–7.5902μg/ml, and Compounds 1 and 5 showed moderate cytotoxicity against MCF-7, H1299 and SMMC-7721 tumor cell lines.
