Clausine D
Clausine D and clausine F show significant antiplatelet aggregation activity, due to inhibition of the formation of thromboxane A2.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Biochim Biophys Acta. 1994 Sep 28;1201(1):1-6.
Antiplatelet effects of clausine D isolated from Clausena excavata.[Pubmed:
7918571 ]
METHODS AND RESULTS:
Clausine D inhibited concentration-dependently the aggregation and release reaction of washed rabbit platelets induced by arachidonic acid and collagen, without affecting those induced by U46619, PAF and thrombin. The IC50 values of Clausine D on arachidonic acid- and collagen-induced platelet aggregation were calculated to be 9.0 +/- 1.1 and 58.9 +/- 0.9 microM, respectively. Thromboxane B2 and prostaglandin D2 formation in platelets caused by arachidonic acid were also suppressed. Clausine D inhibited increased intracellular concentration of calcium in platelets caused by arachidonic acid and collagen, and also abolished the generation of inositol monophosphate caused by arachidonic acid, but not that by collagen, U46619, PAF and thrombin. In human citrated platelet-rich plasma, Clausine D inhibited the secondary phase, but not the primary phase, of aggregation induced by epinephrine and ADP.
CONCLUSIONS:
These results indicate that the antiplatelet effect of Clausine D is due to inhibition of the formation of thromboxane A2.
Chem Pharm Bull (Tokyo). 1992 Apr;40(4):1069-71.
Clausine D and -F, two new 4-prenylcarbazole alkaloids from Clausena excavata.[Pubmed:
1525939]
METHODS AND RESULTS:
Two new 4-prenylcarbazole alkaloids, Clausine D (1) and -F (3) were isolated from the stem bark of Clausena excavata. Their structures were elucidated by spectral methods.
CONCLUSIONS:
Both of Clausine D (1) and -F (3) showed significant antiplatelet aggregation activity.
