Safflospermidine B

Safflospermidine B
Product Name Safflospermidine B
CAS No.: N/A
Catalog No.: CFN95254
Molecular Formula: C34H37N3O6
Molecular Weight: 583.7 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Targets: Tyrosinase
Source: The herbs of Helianthus annuus L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $413/5mg
Safflospermidine B is a potential natural tyrosinase inhibitor, it shows high antityrosinase activity (IC50 of 31.8μM).
Inquire / Order:
Technical Inquiries:
Tel: +86-27-84237783
Fax: +86-27-84254680

1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to:

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Ethnopharmacol.2017, 198:205-213
  • Front Cell Dev Biol.2021, 9:638174.
  • Molecules.2017, 22(2)
  • Int J Mol Sci.2020, 21(8):2790.
  • Cancers (Basel).2021, 13(17):4327.
  • Int Immunopharmacol.2021, 101(Pt A):108181.
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Front Pharmacol.2020, 11:566490.
  • United States Patent Application2020, 20200038363
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • N1,N5,N10-(Z)-tri-p-coumaroylspermidine

    Catalog No: CFN95253
    CAS No: 131086-78-7
    Price: $388/5mg
    Safflospermidine B

    Catalog No: CFN95254
    CAS No: N/A
    Price: $413/5mg
    Safflospermidine A

    Catalog No: CFN95255
    CAS No: N/A
    Price: $413/5mg

    Catalog No: CFN95256
    CAS No: 364368-18-3
    Price: $388/5mg
    Heliyon, 2020, 6(3):e03638.
    Safflospermidines from the bee pollen of Helianthus annuus L. exhibit a higher in vitro antityrosinase activity than kojic acid.[Reference: WebLink]
    Ozone deterioration in the atmosphere has become a severe problem causing overexposure of ultraviolet light, which results in humans in melanin overproduction and can lead to many diseases, such as skin cancer and melasma, as well as undesirable esthetic appearances, such as freckles and hyperpigmentation. Although many compounds inhibit melanin overproduction, some of them are cytotoxic, unstable, and can cause skin irritation. Thus, searching for new natural compounds with antityrosinase activity and less/no side effects is still required. Here, bee pollen derived from sunflower (Helianthus annuus L.) was evaluated.
    Sunflower bee pollen (SBP) was collected from Apis mellifera bees in Lopburi province, Thailand in 2017, extracted by methanol and sequentially partitioned with hexane and dichloromethane (DCM). The in vitro antityrosinase activity was evaluated using mushroom tyrosinase and the half maximal inhibitory concentration (IC50) is reported. The antioxidation activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and reported as the half maximal effective concentration. Two pure compounds with antityrosinase activity were isolated by silica gel 60 column chromatography (SG60CC) and high performance liquid chromatography (HPLC), and their chemical structure deduced by Nuclear Magnetic Resonance (NMR) analysis. The DCM partitioned extract of SBP (DCMSBP) had an antityrosinase activity (IC50, 159.4 μg/mL) and was fractionated by SG60CC, providing five fractions (DCMSBP1–5). The DCMSBP5 fraction was the most active (IC50 = 18.8 μg/mL) and further fractionation by HPLC gave two active fractions, revealed by NMR analysis to be safflospermidine A and Safflospermidine B. Interestingly, both safflospermidine A and Safflospermidine B had a higher antityrosinase activity (IC50 of 13.8 and 31.8 μM, respectively) than kojic acid (IC50 of 44.0 μM). However, fraction DCMSBP5 had no significant antioxidation activity, while fractions DCMSBP1–4 showed a lower antioxidation activity than ascorbic acid.
    Safflospermidine A and Safflospermidine B are potential natural tyrosinase inhibitors.

    Catalog No: CFN95018
    CAS No: 28383-41-7
    Price: $288/5mg

    Catalog No: CFN95054
    CAS No: 83864-78-2
    Price: $388/5mg
    Quercetin 3-O-beta-(6''-p-coumaroyl)glucopyranosyl(1->2)-alpha-L-rhamnopyranoside

    Catalog No: CFN95088
    CAS No: 143061-65-8
    Price: $338/10mg

    Catalog No: CFN95101
    CAS No: 1401414-53-6
    Price: $338/5mg
    5-Hydroxy-1-(4-hydroxyphenyl)-7-phenyl-3-heptanone (AO 2210)

    Catalog No: CFN95137
    CAS No: 105955-04-2
    Price: $268/20mg
    Beta-Dimorphecolic acid (9(S)-HODE)

    Catalog No: CFN95313
    CAS No: 18104-44-4
    Price: $318/5mg
    Apigenin 6,8-di-C-alpha-L-arabinopyranoside

    Catalog No: CFN95360
    CAS No: 73140-47-3
    Price: $318/10mg

    Catalog No: CFN95376
    CAS No: 74064-17-8
    Price: $318/10mg
    Meliotocarpan D

    Catalog No: CFN95401
    CAS No: 83013-81-4
    Price: $413/5mg

    Catalog No: CFN95429
    CAS No: 18997-54-1
    Price: $318/10mg