Garcinone E

Planta Med. 2002 Nov;68(11):975-9.

Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.[Pubmed: 12451486]

Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs.
METHODS AND RESULTS:
We extracted and purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana L., using partitioned chromatography and then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Several commonly used chemotherapeutic agents were included in the assay to determine the relative potency of the potential new drugs.
CONCLUSIONS:
Our results have shown that one of the xanthone derivatives which could be identified as Garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric and lung cancer cell lines included in the screen. We suggest that Garcinone E may be potentially useful for the treatment of certain types of cancer.

Phytother Res. 2010 Oct;24(10):1575-7.

Xanthone constituents of the fruits of Garcinia mangostana with anticomplement activity.[Pubmed: 20878711]

METHODS AND RESULTS:
Phytochemical investigation of a chloroform-soluble fraction of the freeze-dried fruits of Garcinia mangostana (Clusiaceace) with anticomplement activity in the classical pathway led to the identification of five known xanthones. The structures of these compounds were confirmed by interpretation of NMR and MS spectroscopic data.
CONCLUSIONS:
Of the isolates obtained, 1-isomangostin and Garcinone E were found to be active constituents in the anticomplement assay used.