Garcinone E

Garcinone E
Product Name Garcinone E
CAS No.: 112649-21-5
Catalog No.: CFN92697
Molecular Formula: C28H32O6
Molecular Weight: 464.6 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Yellow powder
Targets: Antifection
Source: The fruits of Garcinia mangostana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Microorganisms.2021, 9(12):2514.
  • Biomedicines.2022, 10(3):583.
  • J Chromatogr A.2022, 1685:463640.
  • ACS Synth Biol.2022, 11(10):3296-3304.
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • Vietnam J. Chem.2023, 61(3),308-317
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Chem Res Toxicol.2023, 36(2):213-229.
  • Nat Prod Commun.2014, 9(5):679-82
  • Phytochemistry.2021, 181:112539.
  • Parvifolixanthone A

    Catalog No: CFN89058
    CAS No: 906794-56-7
    Price: Inquiry(manager@chemfaces.com)
    Latisxanthone C

    Catalog No: CFN89046
    CAS No: 197447-32-8
    Price: Inquiry(manager@chemfaces.com)
    Butyraxanthone B

    Catalog No: CFN92696
    CAS No: 1141754-81-5
    Price: Inquiry(manager@chemfaces.com)
    Garcinone E

    Catalog No: CFN92697
    CAS No: 112649-21-5
    Price: Inquiry(manager@chemfaces.com)
    Isogarciniaxanthone E

    Catalog No: CFN97125
    CAS No: 659747-28-1
    Price: Inquiry(manager@chemfaces.com)
    Garciniaxanthone E

    Catalog No: CFN99816
    CAS No: 173294-74-1
    Price: Inquiry(manager@chemfaces.com)
    Sterigmatocystin

    Catalog No: CFN96575
    CAS No: 10048-13-2
    Price: Inquiry(manager@chemfaces.com)
    Griffipavixanthone

    Catalog No: CFN98089
    CAS No: 219649-95-3
    Price: Inquiry(manager@chemfaces.com)
    Bijaponicaxanthone C

    Catalog No: CFN96574
    CAS No: 872409-35-3
    Price: Inquiry(manager@chemfaces.com)
    Planta Med. 2002 Nov;68(11):975-9.
    Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.[Pubmed: 12451486]
    Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs.
    METHODS AND RESULTS:
    We extracted and purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana L., using partitioned chromatography and then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Several commonly used chemotherapeutic agents were included in the assay to determine the relative potency of the potential new drugs.
    CONCLUSIONS:
    Our results have shown that one of the xanthone derivatives which could be identified as Garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric and lung cancer cell lines included in the screen. We suggest that Garcinone E may be potentially useful for the treatment of certain types of cancer.
    Phytother Res. 2010 Oct;24(10):1575-7.
    Xanthone constituents of the fruits of Garcinia mangostana with anticomplement activity.[Pubmed: 20878711]

    METHODS AND RESULTS:
    Phytochemical investigation of a chloroform-soluble fraction of the freeze-dried fruits of Garcinia mangostana (Clusiaceace) with anticomplement activity in the classical pathway led to the identification of five known xanthones. The structures of these compounds were confirmed by interpretation of NMR and MS spectroscopic data.
    CONCLUSIONS:
    Of the isolates obtained, 1-isomangostin and Garcinone E were found to be active constituents in the anticomplement assay used.
    Ginsenoside F5

    Catalog No: CFN95034
    CAS No: 189513-26-6
    Price: $298/20mg
    Licoarylcoumarin

    Catalog No: CFN95072
    CAS No: 125709-31-1
    Price: $413/5mg
    Kaempferol 3-O-beta-(6''-p-coumaroyl)glucopyranosyl(1->2)-alpha-L-rhamnopyranoside

    Catalog No: CFN95089
    CAS No: 111957-48-3
    Price: $338/10mg
    2-O-cinnamoyl-beta-D-glucose

    Catalog No: CFN95111
    CAS No: N/A
    Price: $318/20mg
    Lappaol B

    Catalog No: CFN95242
    CAS No: 62359-60-8
    Price: $333/10mg
    trans-Psoralenoside

    Catalog No: CFN95349
    CAS No: N/A
    Price: $318/5mg
    Toddalolactone 3'-O-methyl ether (6-(2-Hydroxy-3-methoxy-3-methylbutyl)-5,7-dimethoxycoumarin)

    Catalog No: CFN95372
    CAS No: 143614-35-1
    Price: $318/10mg
    10-O-trans-p-coumaroylscandoside

    Catalog No: CFN95391
    CAS No: 870785-25-4
    Price: $318/10mg
    Ganoderic acid Df

    Catalog No: CFN95514
    CAS No: 1352033-73-8
    Price: $318/5mg
    Irigenin 3'-O-glucoside

    Catalog No: CFN95578
    CAS No: N/A
    Price: $318/5mg