Parvifolixanthone A

Chinese Traditional & Herbal Drugs, 2012, 43(3):436-439.

Chemical constituents from stem barks of Garcinia paucinervis.[Reference: WebLink]

To study the chemical constituents from the stem barks of Garcinia paucinervis and their antitumor activities.
METHODS AND RESULTS:
Chemical constituents were isolated and purified from petroleum ether extract of G.paucinervis by chromatography on silica gel,RP-18,Sephadex LH-20 column,and preparative TLC.Their structures were identified on the basis of spectroscopic analysis and chemical evidence.The antitumor activity was screened by MTT assay. Ten compounds were isolated and identified as cambogin(1),pyromeconic acid(2),β-sitosterol(3),daucosterol(4),7-prenyljacareubin(5),Parvifolixanthone A(6),formoxanthone A(7),termicalcicolanone A(8),1,3,5,6-tetrahydroxy-4-prenylxanthone(9),and isogarcinol(10).Compounds 5 and 7 showed moderate cytotoxic activity against HL-60,SMMC-7721,A549,MCF-7,and SW480 cell lines.
CONCLUSIONS:
Compounds 2—5 and 7—10 are isolated from this plant for the first time and the13C-NMR spectroscopic data of compound 5 are firstly reported.

Tetrahedron, 2006, 62(36):8578-8585.

Phloroglucinols, depsidones and xanthones from the twigs of Garcinia parvifolia.[Reference: WebLink]

METHODS AND RESULTS:
Seven phloroglucinols, named parvifoliols A–G (1–7), two depsidones, named parvifolidones A, B (8, 9), and three xanthones, named Parvifolixanthone A, parvifolixanthone B, parvifolixanthone C (10–12), were isolated from the twigs of Garcinia parvifolia along with seven known compounds: garcidepsidone B, mangostinone, rubraxanthone, dulxanthone D, 1,3,5,6-tetrahydroxyxanthone, norathyriol, and (2E,6E,10E)-( )-4β-hydroxy-3-methyl-5β-(3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)cyclohex-2-en-1-one.
CONCLUSIONS:
Their structures were proposed on the basis of spectroscopic data. The antibacterial and antioxidation activities were evaluated.