Latisxanthone C
Latisxanthone C shows inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, it may be a valuable antitumor promoter.
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24 months(2-8C).
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Cancer Lett. 1998 Oct 23;132(1-2):113-7.
Xanthones as inhibitors of Epstein-Barr virus activation.[Pubmed:
10397461]
METHODS AND RESULTS:
To search for possible antitumor promoters, we carried out a primary screening of 20 xanthones isolated from plants of the Guttiferae family, using their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of these xanthones, namely 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone (8), dulxanthone B (10) and Latisxanthone C (15), were observed to significantly inhibit the EBV-EA activation.
CONCLUSIONS:
The investigation indicated that 8, 10 and 15 might be valuable antitumor promoters.
