Silybin A

Silybin A
Product Name Silybin A
CAS No.: 22888-70-6
Catalog No.: CFN95149
Molecular Formula: C25H22O10
Molecular Weight: 482.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: Calcium Channel | ROS
Source: The herbs of Silybum marianum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $368/20mg
Silybin A has oxidative effects, it shows stronger effects on cell growth inhibition and apoptosis induction than silybin.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • University of Limpopo2016, 1-237
  • Plant Physiol Biochem.2021, 160:166-174.
  • Int J Mol Sci.2021, 22(21):11447.
  • J Cell Physiol.2020, 10.1002
  • Food Res Int.2020, 128:108778
  • Nutrients.2020, 12(11):3448.
  • Nature Ecology & Evolution2020, doi: 10.1038
  • PLoS One.2017, 12(3):e0173585
  • BMC Complement Altern Med.2019, 19(1):339
  • University of Central Lancashire2017, 20472
  • Isosilybin B

    Catalog No: CFN91071
    CAS No: 142796-22-3
    Price: $238/5mg
    Silymarin

    Catalog No: CFN99542
    CAS No: 22888-70-6
    Price: $30/20mg
    Silybin A

    Catalog No: CFN95149
    CAS No: 22888-70-6
    Price: $368/20mg
    Silybin B

    Catalog No: CFN92916
    CAS No: 142797-34-0
    Price: $318/10mg
    2,3-Dehydrosilybin A

    Catalog No: CFN70322
    CAS No: 25166-14-7
    Price: Inquiry(manager@chemfaces.com)
    2,3-Dehydrosilybin B

    Catalog No: CFN70271
    CAS No: 142796-24-5
    Price: Inquiry(manager@chemfaces.com)
    Silydianin

    Catalog No: CFN90242
    CAS No: 29782-68-1
    Price: $238/20mg
    Silyamandin

    Catalog No: CFN91143
    CAS No: 1009565-36-9
    Price: $413/5mg
    Silychristin B

    Catalog No: CFN95160
    CAS No: 879325-58-3
    Price: $318/5mg
    Isosilychristin

    Catalog No: CFN95369
    CAS No: 77182-66-2
    Price: $318/5mg
    Natural Product Communications, 2011, 6(6):1653-1656.
    A Comparison of the Diastereoisomers, Silybin A and Silybin B, on the Induction of Apoptosis in K562 cells[Pubmed: 22224281]
    Two diastereoisomers of silybin, Silybin A and silybin B, were separated from silymarin by HPLC in our previous study.
    METHODS AND RESULTS:
    The present study assessed the effects of the diastereoisomers on cell apoptosis, and compared these with their mixture, silybin, in human chronic myeloid leukemia K562 cells. Both isomers showed stronger effects on cell growth inhibition and apoptosis induction than silybin. Compared with silybin B, Silybin A showed higher effects on the production of intracellular reactive oxygen species and Ca2+.
    CONCLUSIONS:
    These results suggest that Silybin A and silybin B have similar potency on apoptosis induction with different oxidative effects. Antagonistic effects may exist between Silybin A and silybin B, partially through ROS production and Ca2+ increase.
    J Nat Prod. 2003 Sep;66(9):1171-4.
    Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, Isolated from Silybum marianum (milk thistle).[Pubmed: 14510591 ]

    METHODS AND RESULTS:
    Two pairs of diastereoisomeric flavonolignans, Silybin A, silybin B, isoSilybin A, and isosilybin B, were successfully separated from Silybum marianum by sequential silica gel column chromatography, preparative reversed-phase HPLC, and recrystallization. Complete stereochemical assignments at C-2, C-3, C-7', and C-8' of these flavonolignans have been achieved.
    CONCLUSIONS:
    On the basis of X-ray crystallographic analysis and optical rotation data, coupled with comprehensive (1)H and (13)C NMR spectral data interpretation including COSY, HMQC, and HMBC, the stereochemistry of these diastereoisomers was determined unambiguously as Silybin A (4), 2R, 3R, 7'R, 8'R; silybin B (5), 2R, 3R, 7'S, 8'S; isoSilybin A (6), 2R, 3R, 7'R, 8'R; and isosilybin B (7), 2R, 3R, 7'S, 8'S.
    Carasiphenol C

    Catalog No: CFN95045
    CAS No: 868168-04-1
    Price: $368/5mg
    Lonicerin

    Catalog No: CFN95055
    CAS No: 25694-72-8
    Price: $168/10mg
    Daidzein-4'-glucoside

    Catalog No: CFN95142
    CAS No: 58970-69-7
    Price: $368/5mg
    Momordicine V

    Catalog No: CFN95164
    CAS No: 1012315-36-4
    Price: $463/5mg
    Lanceolarin

    Catalog No: CFN95166
    CAS No: 15914-68-8
    Price: $318/5mg
    Nardoaristolone B

    Catalog No: CFN95203
    CAS No: 1422517-82-5
    Price: $398/5mg
    Isoeuphorbetin

    Catalog No: CFN95207
    CAS No: 50677-55-9
    Price: $318/5mg
    Peiioside B

    Catalog No: CFN95336
    CAS No: 1610618-91-1
    Price: $318/5mg
    3'-Hydroxy-2,4,5-trimethoxydalbergiquinol

    Catalog No: CFN95410
    CAS No: N/A
    Price: $413/5mg
    2,11,12-Trihydroxy-7,20-epoxy-8,11,13-abietatriene

    Catalog No: CFN95428
    CAS No: 1608462-12-9
    Price: $318/10mg