Mahanimbine
Mahanimbine inhibits AChE activity in a dose-dependent manner.
Mahanimbine can lower the absorption of dietary fat resulting in dietary fat excretion, it can prevent high-fat diet (HFD)-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Mahanimbine and mangiferin increases the glucose utilization in a dose-dependent manner, can prevent obesity and use in management of diabetes.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Pharmacogn Mag. 2013 Jan;9(33):72-5.
Effect of Mangiferin and Mahanimbine on Glucose Utilization in 3T3-L1 cells.[Pubmed:
23661997]
To investigate the effects of mangiferin (xanthone glucoside) and Mahanimbine (carbazole alkaloid) on glucose utilization in 3T3-L1 cells.
METHODS AND RESULTS:
Mangiferin was isolated from stem barks of Mangifera indica and Mahanimbine was isolated from Murraya koenigii leaves. These isolated compounds were subjected to MTT assay and glucose utilization test with 3T3-L1 cells.
Treatment of the 3T3-L1 cells with mangiferin and Mahanimbine increased the glucose utilization in a dose-dependent manner. At a concentration of 1 mM, mangniferin showed 2-fold increase in glucose utilization compared with untreated control. In case of Mahanimbine, the observed effect at 1 mM was almost equivalent to positive control (insulin at 1 μM). Moreover, MTT assay showed that both of these compounds were less toxic at a concentration of 1 mM (nearly 75% cells are viable).
CONCLUSIONS:
The present results indicated that these natural products (mangiferin and Mahanimbine) exhibited potential ethnomedical uses in management of diabetes.
Fitoterapia. 2010 Dec;81(8):1129-33.
Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats.[Pubmed:
20655993]
METHODS AND RESULTS:
The dichloromethane (MKD) and ethyl acetate (MKE) extracts of Murraya koenigii leaves significantly reduced the body weight gain, plasma total cholesterol (TC) and triglyceride (TG) levels significantly when given orally at a dose of 300 mg/kg/day to the high fat diet (HFD) induced obese rats for 2 weeks. The observed antiobesity and antihyperlipidemic activities of these extract are correlated with the carbazole alkaloids present in them. Mahanimbine (1) when given orally (30 mg/kg/day) also significantly lowered the body weight gain as well as plasma TC and TG levels.
CONCLUSIONS:
These findings demonstrate the excellent pharmacological potential of Mahanimbine to prevent obesity.
Phytother Res. 2010 Apr;24(4):629-31.
Acetylcholinesterase inhibitory potential of a carbazole alkaloid, mahanimbine, from Murraya koenigii.[Pubmed:
19943242]
Stem barks of Mangifera indica contain a rich content of mangiferin (xanthone glucoside), whereas Murraya koenigii leaves contain rich sources of Mahanimbine (carbazole alkaloid) and used traditionally for the treatment of diabetes.
METHODS AND RESULTS:
In the search for acetylcholinesterase (AChE) inhibitors from Indian medicinal plants, via bioassay-guided isolation, a carbazole alkaloid, Mahanimbine [3, 5-dimethyl-3-(4- methylpent-3-enyl)-11H-pyrano [5, 6-a] carbazole], was isolated from the petroleum ether extract of the leaves of Murraya koenigii. Inhibition of AChE was evaluated based on Ellman's method using 96-well microplate readers. Mahanimbine inhibited AChE activity in a dose-dependent manner with an IC(50) value of 0.03 +/- 0.09 mg/mL, while galantamine was used as a standard.
CONCLUSIONS:
The AChE inhibitory activity of this carbazole alkaloid has not been reported so far, and this study is the first to reveal this activity in carbazole alkaloid Mahanimbine, isolated from Murraya koenigii.
Biofactors. 2017 Mar;43(2):220-231.
Effect of mahanimbine, an alkaloid from curry leaves, on high-fat diet-induced adiposity, insulin resistance, and inflammatory alterations.[Pubmed:
27663177 ]
Spices and condiments, small but an integral part of the daily diet, are known to affect physiological functions. This study evaluated the effects of Mahanimbine, a major carbazole alkaloid from Murraya koenigii (curry leaves), against progression of high-fat diet (HFD)-induced metabolic complications in mice (male and female).
METHODS AND RESULTS:
Mahanimbine at 2 mg/kg (HFD + LD) and 4 mg/kg (HFD + HD) of body weight was administered daily along with HFD feeding for 12 weeks. At the end of the study, male HFD + LD and HFD + HD groups showed 51.70 ± 3.59% and 47.37 ± 3.73% weight gain, respectively, as compared with 71.02 ± 6.04% in HFD fed mice whereas female HFD + LD and HFD + HD groups showed 24.31 ± 1.68% and 25.10 ± 2.61% weight gain as compared with HFD group with 36.69 ± 3.60% of weight gain. Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Moreover, Mahanimbine treatment improved glucose clearance and upregulated the expression of insulin responsive genes in liver and adipose tissue. Male and female mice showed different traits in development of HFD-induced metabolic disturbances; however, Mahanimbine treatment exerted similar effects in both the sexes. In addition, Mahanimbine lowered the absorption of dietary fat resulting in dietary fat excretion.
CONCLUSIONS:
In conclusion, daily consumption of Mahanimbine and thereby curry leaves may alleviate development of HFD-induced metabolic alterations.
