10-Deacetylcephalomannine
10-Deacetylcephalomannin is also active against PS leukemia in vivo, but it is particularly unstable and forms an equilibrium mixture with its cytotoxic C-7 epimer.
10-Deacetylcephalomannine has growth inhibitory activity against human cancer cell lines such as cervical HeLa adenocarcinoma.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Molecules2021, 26(1),230
Pharmaceutics.2021, 13(11):1839.
Microchemical Journal2018, 137:168-173
Research Square2021, 10.21203.
Molecules 2022, 27(3),1047.
Bio-protocol2018, 9(14):e3301
Biochem Biophys Res Commun.2018, 505(1):194-200
Pharmaceutics.2020, 12(9):882.
Analytical sci. & Tech2016, 186-193
Korean Journal of Pharmacognosy2017, 48(4):320-328
Related and Featured Products
J Nat Prod . 1981 May-Jun;44(3):312-319.
19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana[Pubmed:
7264680]
Activity-guided, chromatographic fractionation for a polar extract of Taxus wallichiana Zucc. (originally identified as Cephalotaxus mannii Hook.) resulted in the isolation of three new KB cytotoxic taxane derivatives. Nmr and ms spectral analyses permitted their characterization as 19-hydroxybaccatin III (3), 10-Deacetylcephalomannine (4), and 10-deacetyltaxol (5). The latter two compounds, which are also active against PS leukemia in vivo, were observed to be especially labile, each forming equilibrium mixtures with their cytotoxic C-7 epimers (9, 10).
