4-Hydroxyphenylacetic acid

4-Hydroxyphenylacetic acid
Product Name 4-Hydroxyphenylacetic acid
CAS No.: 156-38-7
Catalog No.: CFN97923
Molecular Formula: C8H8O3
Molecular Weight: 152.2 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Targets: HIF | VEGFR | Antifection
Source: The herbs of Bulbophyllum odoratissimum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $30/20mg
4-Hydroxyphenylacetic acid has anti-inflammatory activity,it attenuates inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. 4-Hydroxyphenylacetic acid is active against the root-lesion nematode, Pratylenchus penetrans, and the pine wood nematode.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • J Nutr Biochem.2022, 107:109064.
  • J Nat Med.2022, 76(1):59-67.
  • Free Radic Biol Med.2021, 166:104-115.
  • Green Chemistry2021, ISSUE 2.
  • Korean J Dent Mater.2018, 45(2):139-146
  • Int J Mol Sci.2022, 23(10):5813.
  • Methods Protoc.2024, 7(6):95.
  • Plants (Basel).2021, 10(2):278.
  • Ind Crops Prod.2014, 62:173-178
  • 4-(Ethoxymethyl)phenol

    Catalog No: CFN97879
    CAS No: 57726-26-8
    Price: Inquiry(manager@chemfaces.com)
    Gastrodin

    Catalog No: CFN99549
    CAS No: 62499-27-8
    Price: $30/20mg
    Acetagastrodin

    Catalog No: CFN80033
    CAS No: 64291-41-4
    Price: Inquiry(manager@chemfaces.com)
    Calleryanin

    Catalog No: CFN95556
    CAS No: 20300-53-2
    Price: $318/5mg
    Protocatechuic acid 4-O-beta-glucoside

    Catalog No: CFN95557
    CAS No: 7361-59-3
    Price: $413/5mg
    Odontoside

    Catalog No: CFN95530
    CAS No: 20300-50-9
    Price: $318/5mg
    (3,4-Dihydroxyphenyl)methyl 3-(beta-D-glucopyranosyloxy)-4-hydroxybenzoate

    Catalog No: CFN95531
    CAS No: 877461-90-0
    Price: $318/10mg
    Protocatechuoylcalleryanin-3-O-beta-glucopyranoside

    Catalog No: CFN95610
    CAS No: 1263431-59-9
    Price: $318/10mg
    Caffeoylcalleryanin

    Catalog No: CFN95532
    CAS No: 20300-49-6
    Price: $318/10mg
    2-(4-Hydroxyphenyl)ethanol

    Catalog No: CFN98792
    CAS No: 501-94-0
    Price: $30/20mg
    Int J Mol Sci. 2014 Jul 21;15(7):12861-84.
    4-hydroxyphenylacetic acid attenuated inflammation and edema via suppressing HIF-1α in seawater aspiration-induced lung injury in rats.[Pubmed: 25050781]
    4-Hydroxyphenylacetic acid (4-HPA) is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases.
    METHODS AND RESULTS:
    The aim of this study is to investigate the effect of 4-Hydroxyphenylacetic acid on seawater aspiration-induced lung injury. Hypoxia-inducible factor-1α (HIF-1α) siRNA and permeability assay were used to study the effect of 4-Hydroxyphenylacetic acid on the production of inflammatory cytokines and monolayer permeability in vitro. The results showed that 4-Hydroxyphenylacetic acid reduced seawater instillation-induced mortality in rats. In lung tissues, 4-Hydroxyphenylacetic acid attenuated hypoxia, inflammation, vascular leak, and edema, and decreased HIF-1α protein level. In primary rat alveolar epithelial cells (AEC), 4-Hydroxyphenylacetic acid decreased hypertonicity- and hypoxia-induced HIF-1α protein levels through inhibiting the activations of protein translational regulators and via promoting HIF-1α protein degradation. In addition, 4-Hydroxyphenylacetic acid lowered inflammatory cytokines levels through suppressing hypertonicity- and hypoxia-induced HIF-1α in NR8383 macrophages. Moreover, 4-Hydroxyphenylacetic acid decreased monolayer permeability through suppressing hypertonicity and hypoxia-induced HIF-1α, which was mediated by inhibiting vascular endothelial growth factor (VEGF) in rat lung microvascular endothelial cell line (RLMVEC).
    CONCLUSIONS:
    In conclusion, 4-Hydroxyphenylacetic acid attenuated inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats.
    Z Naturforsch C. 2011 Jan-Feb;66(1-2):31-4.
    Nematicidal activities of 4-hydroxyphenylacetic acid and oidiolactone D produced by the fungus Oidiodendron sp.[Pubmed: 21476434]

    METHODS AND RESULTS:
    Two nematicides, 4-Hydroxyphenylacetic acid (4-HPA) (1) and oidiolactone D (2), were isolated from cultures of the fungus Oidiodendron sp., and their structures were identified by spectroscopic analyses. Compound 2 showed nematicidal activities against the root-lesion nematode, Pratylenchus penetrans, and the pine wood nematode, Bursaphelenchus xylophilus.
    CONCLUSIONS:
    4-Hydroxyphenylacetic acid was also active against these two nematodes but to a lesser extent.
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    Buddlenoid A

    Catalog No: CFN95025
    CAS No: 142750-32-1
    Price: $368/5mg
    Carasiphenol C

    Catalog No: CFN95045
    CAS No: 868168-04-1
    Price: $368/5mg
    3''-Galloylquercitrin

    Catalog No: CFN95048
    CAS No: 503446-90-0
    Price: $368/5mg
    Rhamnocitrin 3-glucoside

    Catalog No: CFN95134
    CAS No: 41545-37-3
    Price: $318/10mg
    Neoarctin B

    Catalog No: CFN95243
    CAS No: 155969-67-8
    Price: $318/10mg
    Vaccarin E

    Catalog No: CFN95252
    CAS No: 2252345-81-4
    Price: $318/10mg
    Arvenin III

    Catalog No: CFN95327
    CAS No: 65597-45-7
    Price: $318/5mg
    Apigenin 7-[rhamnosyl-(1->2)-galacturonide]

    Catalog No: CFN95352
    CAS No: 124167-97-1
    Price: $318/10mg
    Pinocembroside

    Catalog No: CFN95444
    CAS No: 75829-43-5
    Price: $118/20mg