Methyl 4-Hydroxyphenylacetate
Methyl 4-Hydroxyphenylacetate has potent inhibitory activity against tobacco mosaic virus (TMV).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
Separations2023, 10(7), 411.
Korean Journal of Medicinal Crop Science2018, 26(5):382-390
Int J Mol Sci.2021, 22(16):8641.
BMC Plant Biol.2021, 21(1):60.
Biomed Chromatogr.2020, e5021.
J Cell Mol Med.2020, 24(21):12308-12317.
Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
United States Patent Application2020, 20200038363
Nat Commun.2023, 14(1):8142.
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Nat Prod Res. 2013;27(24):2286-91.
A novel and other bioactive secondary metabolites from a marine fungus Penicillium oxalicum 0312F1.[Pubmed:
23962399 ]
A new compound 2-(4-hydroxybenzoyl) quinazolin-4(3H)-one (1) and four known compounds were isolated from a marine fungus Penicillium oxalicum 0312F1.
METHODS AND RESULTS:
The structure of the new compound 1 was elucidated based on the spectroscopic analysis. Bioactivity assays showed that 2-(4-hydroxybenzyl) quinazolin-4(3H)-one (2) and Methyl 4-Hydroxyphenylacetate (5) had potent inhibitory activity against tobacco mosaic virus (TMV), and the new compound 1 had moderate inhibitory activity against TMV and human gastric cancer cell SGC-7901.
J Sep Sci. 2017 Jun 5.
A simple, selective, and sensitive gas chromatography-mass spectrometry method for the analysis of five process-related impurities in atenolol bulk drug and capsule formulations.[Pubmed:
28581679 ]
METHODS AND RESULTS:
An extremely sensitive and simple gas chromatography with mass spectrometry method was developed and completely validated for the analysis of five process-related impurities, viz., 4-hydroxy-l-phenylglycine, 4-hydroxyphenylacetonitrile, 4-hydroxyphenylacetic acid, Methyl 4-Hydroxyphenylacetate, and 2-[4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl]acetonitrile, in atenolol. The separation of impurities was accomplished on a BPX-5 column with dimensions of 50 m × 0.25 mm i.d. and 0.25 μm film thickness.
CONCLUSIONS:
The method validation was performed following International Conference on Harmonisation guidelines in which the method was capable to quantitate 4-hydroxy-l-phenylglycine, 4-hydroxyphenylacetonitrile, and 4-hydroxyphenylacetic acid at 0.3 ppm, and methyl-4-hydroxyphenylacetate and 2-[4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl]acetonitrile at 0.35 ppm with respect to 10 mg/mL of atenolol.
