1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone
1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone has moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against Candida albicans.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
University of Central Lancashire2017, 20472
J Biosci.2020, 45:46.
Int J Mol Sci.2017, 19(1)
Phytomedicine.2019, 56:48-56
Process Biochemistry2019, 85:106-115
Planta Med.2019, 85(3):217-224
Food Sci Biotechnol.2023, 32(9):1215-1223.
Antioxidants (Basel).2020, 9(2):E99
Nat Prod Sci.2018, 24(3):206
Huazhong Agricultural University2022, pp34.
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Chem Biodivers. 2007 May;4(5):940-6.
Cytotoxic prenylated phenolic compounds from the twig bark of Garcinia xanthochymus.[Pubmed:
17511007]
METHODS AND RESULTS:
Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments.
CONCLUSIONS:
All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.
