Pancixanthone A

Fitoterapia. 2008 Jan;79(1):42-6.

Antileishmanial polyphenols from Garcinia vieillardii.[Pubmed: 17826924 ]

METHODS AND RESULTS:
Seven xanthones, the new vieillardiixanthones B and C (1) and (7), Pancixanthone A (2),pancixanthone B (3), 1,6-dihydroxyxanthone (6), pyranojacareubin and 5,6-O-dimethyl-2-deprenylrheediaxanthone together with two benzophenones, clusiachromene (4) and 3-geranyl-2,4,6-trihydroxybenzophenone (5) were isolated from the stem bark of the neocaledonian Garcinia vieillardii.
CONCLUSIONS:
2, 5 and 6 showed a significant antileishmanial activity against the promastigote forms of Leishmania mexicana and L. infantum and against the amastigote forms of L. infantum.

Yao Xue Xue Bao. 2009 Feb;44(2):154-7.

Xanthones from leaves of Calophyllum inophyllum Linn.[Pubmed: 19408685]

METHODS AND RESULTS:
To study the xanthones from the leaves of Calophyllum inophyllum Linn., several chromatography methods were employed to isolate the constituents. Investigation on the CHCl3 extract led to the isolation of a new xanthone named inophyxanthone A (1) and four known compounds, which were Pancixanthone A (2), gerontoxanthone B (3), jacareubin (4) and pyranojacareubin (5). Among them, compound 2 was obtained from this plant firstly, and compound 3 was obtained for the first time from this genus.
CONCLUSIONS:
The structure of inophyxanthone A (1) was identified as 1, 3, 5-trihydroxy-2-(1, 1-dimethylallyl)xanthone by spectral analysis.

Life Sci. 2004 Nov 5;75(25):3077-85.

Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii.[Pubmed: 15474559 ]

METHODS AND RESULTS:
The antimalarial activity of 22 xanthones against chloroquino-resistant strains of Plasmodium falciparum was evaluated. Natural caloxanthone C (1), demethylcalabaxanthone (2), calothwaitesixanthone (3), calozeyloxanthone (4), dombakinaxanthone (5), macluraxanthone (6), and 6-deoxy-gamma-mangostin (7) were isolated from Calophyllum caledonicum. 1,6-dihydroxyxanthone (8), Pancixanthone A (9), isocudraniaxanthone B (10), isocudraniaxanthone A (11), 2-deprenylrheediaxanthone B (12) and 1,4,5-trihydroxyxanthone (13) were isolated from Garcinia vieillardii. Moreover, synthetic compounds (14-22) are analogues or intermediates of xanthones purified from Calophyllum caledonicum. The relationship between antimalarial activity and molecular structure of xanthones has also been explored.
CONCLUSIONS:
The most potent xanthones (2), (3) and (7) (IC50 = c.a. 1.0 microg/mL) are 1,3,7 trioxygenated and prenylated on the positions 2 and 8.