Pyrazolanthrone (SP600125)
Catalog No: CFN60010
SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A，FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.
Pyrogallol
Catalog No: CFN97443
Pyrogallol is a polyphenol compound, which has anti-fungal, anti-psoriatic, anti-inflammatory, and antiproliferative effects . Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions; it is both a sensitizer, a carcinogenic, and an irritant in female BALB/c mice.
