Sanguinarine
Catalog No: CFN98259
Sanguinarine possesses anticancer, antimicrobial, anti-inflammatory, and antioxidant properties, it has therapeutic potential in preventing the neurodegenerative diseases, it
may be used to develop a potential therapeutic drug for treating cardiac remodeling and heart failure and shows protective effects on teeth and alveolar bone health. Sanguinarine can inhibit osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-κB and ERK signaling pathways, and can protect against cardiac hypertrophy and fibrosis via inhibiting NF-κB activation.
Saponin V
Catalog No: CFN90781
Saponin V exhibits significant antitussive, expectorant and antispasmodic effects, it (300,150,75 mg·kg-1) can significantly decrease the times of cough, saponin V 300 mg/kg can remarkably increase cough latent period, saponin V 5 g/L remarkably antagonized contraction of isolated ileum, saponin V 2.5 and 1.25 g/L antagonized trachea spasm in guinea pig induced by histamine.Chikusetsu saponin V exhibits neuroprotective effects, it can attenuate H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1α/Mn-SOD signaling pathways.
Sappanchalcone
Catalog No: CFN97522
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor. Sappanchalcone has cytoprotective, and anti-inflammatory effects, it could be used as an anti-inflammatory and bone-protective agent during the treatment of rheumatoid arthritis. Sappanchalcone blocks cell cycle progression in the G2/M phase, it suppresses oral cancer cell growth and induces apoptosis through the activation of p53-dependent mitochondrial, p38, ERK, JNK, and NF-κB signaling, could potentially used to treat periodontal, pulpal , periapical inflammatory lesion and oral cancer. Sappanchalcone possesses the most potent effect against allergic reaction in basophilic leukemic (RBL-2H3) cells with an inhibitory concentration (IC50) value of 7.6 uM, it may have anti-allergic activity.
