Saikosaponin A
Catalog No: CFN99987
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-inflammatory, immunomodulatory, and anti-bacterial activities. It extends to alcohol self-administration the capacity to suppress morphine and cocaine self-administration in rats, and can effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord. It can inhibit NMDA receptor current and persistent sodium current, and inhibit the TNF-α level, the IL-1β production, and cysteine-aspartic acid protease (caspase)-1 activity.
Saikosaponin D
Catalog No: CFN99989
Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is also an agonist of the glucocorticoid receptor (GR),which has anti-cancer, anti-inflammatory, and neuroprotective effects. Saikosaponin D protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling; it shows inhibitory effects on NF-κB activation and thereby on iNOS, COX-2 and pro-inflammatory cytokines.
