Wilfornine A
Wilfornine A is a natural product from Schisandra sphenanthera.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Ecol Evol.2022, 12(11):e9459.
ACS Pharmacol. Transl. Sci.2022, 5,7,479-490
Pharmacogn Mag.2015, 11(43):562-6
Pharmaceutics2022, 14(2),376.
Natural Product Communications2023, 18(9).
Environ Toxicol.2020, doi: 10.1002
Korean Journal of Pharmacognosy2018, 49(4):349-361
Mol Cancer Ther.2024, 1535-7163.
J Nutr Biochem.2022, 107:109064.
Food Research International2023, 113792.
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J Nat Prod. 2001 May;64(5):582-7.
Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii.[Pubmed:
11374948]
Nine new sesquiterpene pyridine alkaloids [Wilfornine A (1), wilfornine B (2), wilfornine C (3), wilfornine D (4), wilfornine E (5), wilfornine F (8), and wilfornine G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (T(II)) of Tripterygium wilfordii.
METHODS AND RESULTS:
The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.
