Trilobinine
(+)-Trilobinine has relaxant effects via the activation of beta 2-adrenoceptors, it can reduce the spontaneous tone and inhibit the contractions induced by carbachol and histamine.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Planta Med. 1999 Jun;65(5):462-4.
Tracheal relaxant activity of cissaglaberrimine and trilobinine, two aporphinic alkaloids from Cissampelos glaberrima.[Pubmed:
10418339]
In the present work we studied the relaxant effect of two aporphinic alkaloids isolated from the roots barks of Cissampelos glaberrima St. Hil. (Menispermaceae), (+)-cissaglaberrimine (CGE; a tertiary alkaloid) and (+)-Trilobinine (TBE; a quaternary alkaloid).
METHODS AND RESULTS:
In guinea-pig tracheal preparations, CGE and TBE reduced the spontaneous tone and inhibited the contractions induced by carbachol and histamine. TBE was 6 times more potent than CGE in reducing the spontaneous tone and it was also 1.5 times more potent in antagonising the effects of carbachol and histamine. The inhibitory effect of CGE in contractions induced by histamine was not attenuated in the presence of timolol (10 microM). However, in the same experimental conditions, timolol almost completely abolished the inhibitory effect of TBE.
CONCLUSIONS:
These results showed that the relaxations induced by TBE were dependent on the activation of beta 2-adrenoceptors, while the mechanism involved in relaxations induced by CGE remains to be determined.
