Shegansu B

Planta Med. 2010 Nov;76(16):1874-6.

In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum.[Pubmed: 20539973]

METHODS AND RESULTS:
The anti-influenza viral activities of six stilbenoids from the lianas of Gnetum pendulum C. Y. Cheng were evaluated with two different assays, neuraminidase (NA) activity assay and cytopathic effect (CPE) reduction assay.
CONCLUSIONS:
The NA assay results showed that all six stilbenoids exerted an NA inhibitory effect, while the CPE assay indicated that among them, isorhapontigenin (2), gnetupendin B (3), Shegansu B (4), and gnetin D 6) exhibit significant in vitro anti-influenza viral activity in MDCK cells, with IC(50) values from 0.67 to 11.99 µg/mL in comparison to the positive controls oseltamivir acid and ribavirin whose IC(50) values were 0.040 and 5.54 µg/mL, respectively.

J Asian Nat Prod Res. 2000;2(3):169-75.

A new stilbene dimer--shegansu B from Belamcanda chinensis.[Pubmed: 11256690]

METHODS AND RESULTS:
A new dimeric stilbene, named Shegansu B (1) was isolated from the ethanolic extract of the roots of Belamtantida chinensis (L.) DC., along with the known compounds isorhapontigenin, resveratol, p-hydroxybenzoic acid, iridin, tectoridin, tectorigenin and daucosterol. The structures were elucidated by means of spectroscopic evidence including 2D-NMR studies.